Protein Alignment foxo and foxa2

DIOPT Version :10

• Sequence 1: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_571024.1
• Gene: foxa2 / 30126
• ZFINID: ZDB-GENE-980526-404
• Length: 409
• Species: Danio rerio
• Alignment Length: 494
• Identity: 101/494 - (20%)
• Similarity: 173/494 - (35%)
• Gaps: 168/494 - (34%)

  Fly     2 MDG--YAQEW----------PRLTHTDNGLAMDQLG---------------------------GD 27
            |:|  :|.:|          ..:::.:.||.|:.:.                           |.
Zfish     7 MEGHEHAADWSTYYGEPECYTSVSNMNTGLGMNSMNTYMTMSGMSSTANMTAANTMNMSYVNTGM 71

  Fly    28 LPLDVGFEPQTRARSNTW-----------PCPRPENFVEPTDELDSTKASNQQLAPGDSQQAIQN 81
            .|...|..|.|.|.:...           |...|.....|:....::.::...::|...|   .|
Zfish    72 SPSMTGMSPGTGAMAGMGAGMTGMSAALSPTMSPMAAQAPSMNALTSYSNMNAMSPMYGQ---SN 133

  Fly    82 ANAAKKNSSRRNAWGN----LSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSA 142
            .|.::...:.|.::.:    .||..|||.||..:..|.||||:||:|::...|:::     .:..
Zfish   134 INRSRDPKTYRRSYTHAKPPYSYISLITMAIQQSPSKMLTLSEIYQWIMDLFPFYR-----QNQQ 193

  Fly   143 GWKNSIRHNLSLHNRFMRVQN--EGTGKSSWWMLNPEAKPGKSVRRRAASMETSRYEKRRGRAK- 204
            .|:|||||:||.::.|::|..  :..||.|:|.|:|::         ....|...|.:|:.|.|
Zfish   194 RWQNSIRHSLSFNDCFLKVPRSPDKPGKGSFWTLHPDS---------GNMFENGCYLRRQKRFKC 249

  Fly   205 -KRVEALRQAGVVGLNDATPSPSSSVSEGLDHFPESPLHSGGGFQLSPDFRQRASSNASSC-GRL 267
             |::              :..||...|||                       .::|::.|| |..
Zfish   250 DKKL--------------SKDPSRKTSEG-----------------------GSNSSSESCNGNE 277

  Fly   268 SPIRAQDLEPDWGFPVDYQNTTMTQAHAQALEELTGTMADELTLCNQQQQGFSAASGLPSQPPPP 332
            ||               :.|::.        .||..:::|           ..:..||.......
Zfish   278 SP---------------HSNSSS--------NELKRSLSD-----------MKSGQGLSPDHAAS 308

  Fly   333 PYQPPQHQQAQQQQ--------QQQSPYALNGPASGYNTLQPQSQCLLHRSLNC----SCMHNAR 385
            |....||..||...        :.:..|:.|.|.|..|.:..:.|   |..::.    ..||...
Zfish   309 PTSQAQHLLAQHHSVLAHEGHLKPEHHYSFNHPFSINNLMSSEQQ---HHKMDLKTYEQVMHYGY 370

  Fly   386 DGLSPNSVTTTM----SPAYPNSEPSSDSLNTYSNVVLD 420
            .  ||.:.|.:|    |.|..:|..:|.....||..:|:
Zfish   371 G--SPMAGTLSMGSMASKAGLDSPDTSYYQGVYSRPILN 407

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	30/84 (36%)
foxa2	NP_571024.1	Forkhead_N	18..150	CDD:369872	17/134 (13%)
		FH_FOXA2	149..250	CDD:410813	37/114 (32%)
		COG5025	<150..364	CDD:227358	67/301 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	250..315		19/135 (14%)
		HNF_C	339..398	CDD:430552	16/63 (25%)