Protein Alignment foxo and Foxo3

DIOPT Version :9

• Sequence 1: NP_001262557.1
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_001099865.1
• Gene: Foxo3 / 294515
• RGDID: 1309196
• Length: 672
• Species: Rattus norvegicus
• Alignment Length: 683
• Identity: 225/683 - (32%)
• Similarity: 293/683 - (42%)
• Gaps: 201/683 - (29%)

  Fly    27 DLPLDVGFEPQTRARSNTWPCPRPENFVEPT-------------------DELDS---------- 62
            ::.||..||||:|.||.|||..|||....|.                   |:.||
  Rat    15 EVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEDDDEDDEDSGGRGSSAMVI 79

  Fly    63 --------------------------------------------TKASNQQLAPGDSQQAIQNAN 83
                                                        |:...||..|.....|...:.
  Rat    80 GGGVSSALGSGLLLEDSARLLSPGGQDLGTGPASSAGALSGGTQTQLQPQQPLPPPQPGAAGGSG 144

  Fly    84 AAKKNSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSI 148
            ..:|.|||||||||||||||||.||.|:.||||||||||||||:.||||||||||||||||||||
  Rat   145 QPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSI 209

  Fly   149 RHNLSLHNRFMRVQNEGTGKSSWWMLNPE-AKPGKSVRRRAASMETS-RYEKRRGRAKKRVEALR 211
            |||||||:||||||||||||||||::||: .|.||:.||||.||:.| :|.|.||||.|:..||:
  Rat   210 RHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQ 274

  Fly   212 QAGVVGLNDATPSPSSSVSEGLDHFPESPL-HSGGGFQLSPDFRQRASSNASS-CGRLSPIRA-- 272
            .|.    ..|..|||.     |..:|.||. .|........|||.|.:||||: .||||||.|
  Rat   275 AAP----ESADDSPSQ-----LSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPILAST 330

  Fly   273 --QDLEPDWG--FPVDYQNTTMTQ--------AHAQALEELTGTM--------------ADELTL 311
              .|::.|.|  .|:.|.::....        .....|.::.|||              .|.:.|
  Rat   331 ELDDVQDDDGPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLNDGLAENLMDDLLDNIAL 395

  Fly   312 ----------CNQQQQGF---SAASGLPSQPPPPPYQPPQHQQAQQQQQQQSPYAL---NGPAS- 359
                      ..|:...|   :.:|||.|  |...:.......|.....:|||...   |.||:
  Rat   396 PPSQASPPGGLMQRSSSFPYTAKSSGLGS--PTSSFNSTVFGPASLNSLRQSPMQTIQENRPATF 458

  Fly   360 ------GYNTLQ---------------PQSQCLLHRSLNCSCMHNARDGLSPNSVTTTMSPAYPN 403
                  |..|||               .||..|:.::.......|||..:...: ...||.|
  Rat   459 SSVSHYGNQTLQDLLTSDSLSHSDVMMTQSDPLMSQASTAVSAQNARRNVMLRN-DPMMSFA--- 519

  Fly   404 SEPSSDSL-----------------------NTYSNVVLDGPADTAALMVQQQQQQQQQQQLSAS 445
            ::|:..||                       |:.||:   |.:|:::|...:.|||....|...:
  Rat   520 AQPTQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNM---GLSDSSSLGSAKHQQQSPVSQSMQT 581

  Fly   446 LEDNNCASTLIGQC--LEVLNNEAQP----IDEFNLENFPVGNLECNVEELLQQEMSYGGLLDIN 504
            |.|:...|:|....  |.|:.::..|    :|.||      |:|||::|.:::.|:.....||.|
  Rat   582 LSDSLSGSSLYSASANLPVMGHDKFPSDLDLDMFN------GSLECDMESIIRSELMDADGLDFN 640

  Fly   505 IPLATVNTNLVNSSSGPLSISNISNLSNISSNS 537
            ........|:|.     |::.|.:.....||.|
  Rat   641 FDSLISTQNVVG-----LNVGNFTGAKQASSQS 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_001262557.1	FH	95..175	CDD:238016	71/79 (90%)
Foxo3	NP_001099865.1	FH_FOXO3	156..238	CDD:410835	72/81 (89%)
		FOXO_KIX_bdg	432..506	CDD:406960	16/73 (22%)
		FOXO-TAD	605..643	CDD:406961	13/43 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4131
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	292	1.000	Inparanoid score	I2689
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1160384at2759
OrthoFinder	1	1.000	-	-		FOG0000837
OrthoInspector	1	1.000	-	-		otm45200
orthoMCL	1	0.900	-	-		OOG6_108778
Panther	1	1.100	-	-	O	PTHR45767
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X489
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830