Protein Alignment foxo and fhl1

DIOPT Version :10

• Sequence 1: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_594272.1
• Gene: fhl1 / 2541552
• PomBaseID: SPAC1142.08
• Length: 743
• Species: Schizosaccharomyces pombe
• Alignment Length: 566
• Identity: 133/566 - (23%)
• Similarity: 205/566 - (36%)
• Gaps: 151/566 - (26%)

  Fly    35 EPQTRARSNTWP--------CPRPENFVEPTDELDSTKASNQQLAPGDSQQAIQNANAAKKNSSR 91
            :|..|..|:..|        .|:..|..|...:..||..|:..|.| |...:....:|.:|
pombe   232 QPYVRPTSDERPIETDSSVSAPKVANHDEELKQGKSTSPSDTVLHP-DLNGSPDTGDATQK---- 291

  Fly    92 RNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSIRHNLSLHN 156
                .|||||:||...:.:..:|::||..|.||:..|..|::     :....|.|||||||||:.
pombe   292 ----PNLSYANLIARTLIANPNKKMTLGDICEWIANNWSYYR-----HQPPAWHNSIRHNLSLNK 347

  Fly   157 RFMRV---QNEGTGKSSWWMLNP---EAKPGKSVRRR---------AASMETSRYEKRRGRAKKR 206
            .|:|:   ||| .||.|:|||:|   :...|...||.         ||..:|:|        :..
pombe   348 AFIRIPRRQNE-PGKGSFWMLDPSYIDQFEGNFFRRTKKPTPSATPAAHPDTAR--------ENE 403

  Fly   207 VEALRQAGVVGLNDATPSPSSSVS---------EGLDHFPESPLHSG--------GGFQLSPDFR 254
            :.|::..|:........:|....|         |.::..|:|.|.:|        |...|:|:|.
pombe   404 LAAIQTKGISAGKTEQLNPQKETSRSKTHTSRGENVEDRPQSLLQNGIQPIIMRDGKLALNPEFF 468

  Fly   255 QRASS-----NASSCGRLSPIRAQDLEPDWGFPVDYQNTTMTQAHAQALEELTGTMADELTLCNQ 314
            :.|:.     |..:...:|.:: |.:....| |....|.....|.|.|   |...:|.:|.....
pombe   469 KNANGEQQAPNEQAVQAISLLQ-QHINKQLG-PAAANNPEQATAIANA---LAVALAQKLQKQQT 528

  Fly   315 QQQGFSAASGLPSQPPPPPYQPPQHQQAQQQQQQQSPYALNGPASGYNTLQPQSQCLLHRSLNCS 379
            |.||                    .||.|||.:::..|.       ...|.|....:.|.::.
pombe   529 QMQG--------------------PQQVQQQAKRRKAYT-------SQQLNPAPTAMPHPNIT-- 564

  Fly   380 CMHNARDGLSPN-SVTTTMSPAY-----PNSEPSSDSLNTYSNVVLDGPADTAALMVQQQQQQQQ 438
                     ||: |::.|..||.     |...||:.|....:...:..|....|:
pombe   565 ---------SPSPSISVTQRPAVNVGPPPYVRPSAPSKLPDTRQSIGDPLPPGAM---------- 610

  Fly   439 QQQLSA---SLEDNNCASTLIGQCLEVLNNEAQPIDEFNLENFPVGNLECNVEELLQQEMSYGGL 500
             ..:||   |:..::..||......|:.:::       ||...|:.....:...|....
pombe   611 -ANVSAGPSSVRSSSYNSTASESKSEITSHQ-------NLHTIPINKPFTSDRPLYSSP------ 661

  Fly   501 LDINIPLATVNTNLVNSSSGPLSISNISNLS--NISSNSGSSLSLN 544
               |..|..|.|.  |......||.|.|:.|  :|..|...|...|
pombe   662 ---NDTLERVETG--NQGQRMNSIGNASSFSKRDIMENENGSFDTN 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	35/81 (43%)
fhl1	NP_594272.1	COG5025	1..564	CDD:227358	97/386 (25%)