Protein Alignment foxo and Foxa2

DIOPT Version :10

• Sequence 1: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_001386014.1
• Gene: Foxa2 / 25099
• RGDID: 2808
• Length: 465
• Species: Rattus norvegicus
• Alignment Length: 370
• Identity: 93/370 - (25%)
• Similarity: 143/370 - (38%)
• Gaps: 103/370 - (27%)

  Fly    65 ASNQQLAPGDSQQAIQNANAAKK-NSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQN 128
            |:...::|...|..:..|...|. ..|..:|....||..|||.||..:.:|.||||:||:|::..
  Rat   134 ANMNSMSPMYGQAGLSRARDPKTYRRSYTHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDL 198

  Fly   129 VPYFKDKGDSNSSAGWKNSIRHNLSLHNRFMRVQN--EGTGKSSWWMLNPEAKPGKSVRRRAASM 191
            .|:::     .:...|:|||||:||.::.|::|..  :..||.|:|.|:|::         ....
  Rat   199 FPFYR-----QNQQRWQNSIRHSLSFNDCFLKVPRSPDKPGKGSFWTLHPDS---------GNMF 249

  Fly   192 ETSRYEKRRGRAK-KRVEALRQAGVVGLNDATPSPSSSVSEGLDHFPESPLHSGGGFQLSPDFRQ 255
            |...|.:|:.|.| ::..||::|...|                         ||||.:.:|..:.
  Rat   250 ENGCYLRRQKRFKCEKQLALKEAAGAG-------------------------SGGGKKTAPGTQA 289

  Fly   256 RASSNASSCGRLSPIRAQDLEPDWGFPVDYQNTTMTQAHAQ-ALEELTGTMADELT------LCN 313
            .......:.|..|...|....|       :.:.:..|.|.: .|.||.||.|..|:      ...
  Rat   290 SQVQLGEAAGSASETPAGTESP-------HSSASPCQEHKRGGLSELKGTPASALSPPEPAPSPG 347

  Fly   314 QQQQGFSAASGL---PSQP--PPPPYQPPQHQQAQQQQQQQSPYALNGPASGYNTLQPQSQCLLH 373
            ||||   ||:.|   |..|  ||..:..|:|.           ||.|.|.|..|.:..:.|  .|
  Rat   348 QQQQ---AAAHLLVPPHHPGLPPEAHLKPEHH-----------YAFNHPFSINNLMSSEQQ--HH 396

  Fly   374 RSLNCSCMHNARDGLSPNSVTTTMSPAYPNSEPSSDSLNTYSNVV 418
            .|                         :.:.:|....|.||..|:
  Rat   397 HS-------------------------HHHHQPHKMDLKTYEQVM 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	30/80 (38%)
Foxa2	NP_001386014.1	Forkhead_N	23..164	CDD:369872	6/29 (21%)
		FH_FOXA2	163..264	CDD:410813	38/114 (33%)
		COG5025	<164..380	CDD:227358	75/275 (27%)
		HNF_C	380..454	CDD:430552	12/64 (19%)