Protein Alignment foxo and Foxa1

DIOPT Version :10

• Sequence 1: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: XP_038967720.1
• Gene: Foxa1 / 25098
• RGDID: 2807
• Length: 475
• Species: Rattus norvegicus
• Alignment Length: 435
• Identity: 104/435 - (23%)
• Similarity: 159/435 - (36%)
• Gaps: 122/435 - (28%)

  Fly    33 GFEPQTRARSNTWPCPRPENFVEPTDELDSTKASNQQLAPGDSQQAIQNANAAKKNSSRRNAWGN 97
            |..|...|.:   ||..|..:. |:: |..::|.    ..||::...::...||.         .
  Rat   126 GLGPYAAAMN---PCMSPMAYA-PSN-LGRSRAG----GGGDAKTFKRSYPHAKP---------P 172

  Fly    98 LSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSIRHNLSLHNRFMRVQ 162
            .||..|||.||..|..|.||||:||:|::...||::     .:...|:|||||:||.::.|::|.
  Rat   173 YSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYR-----QNQQRWQNSIRHSLSFNDCFVKVA 232

  Fly   163 N--EGTGKSSWWMLNPEAKPGKSVRRRAASMETSRYEKRRGRAKKRVEALRQAGV---------V 216
            .  :..||.|:|.|:|::         ....|...|.:|    :||.:..:|.|.         .
  Rat   233 RSPDKPGKGSYWTLHPDS---------GNMFENGCYLRR----QKRFKCEKQPGAGGGSGGGGSK 284

  Fly   217 GLNDATPSPSSSVSEGLDHFPESPLHSG--GGFQLSPDFRQRASSNASSCGRLSPIRAQDLEPDW 279
            |:.:....||..|:..    .|||:|.|  |                         :|..||
  Rat   285 GVPENRKDPSGPVNPS----AESPIHRGVHG-------------------------KASQLE--- 317

  Fly   280 GFP----------VDYQNTTMTQAHAQALEELTGTMADELTLCNQQQQGFSAASGLPSQPPPPPY 334
            |.|          :|:...|.| ..|..|:....:.|..::         |....|.|.||..|.
  Rat   318 GAPAPGPAASPQTLDHSGATAT-GGASELKSPASSSAPPIS---------SGPGALASVPPSHPA 372

  Fly   335 QPPQHQQAQQQQQQQSPYALNGPASGYNTLQPQSQCLLHRSLNCSCMHNARDGLSPNSVT----- 394
            ......::|...:....|:.|.|.|..|.:....|   ...|:......|.. .||...|
  Rat   373 HGLAPHESQLHLKGDPHYSFNHPFSINNLMSSSEQ---QHKLDFKAYEQALQ-YSPYGATLPASL 433

  Fly   395 -------TTMSPAYPNS-EPSSDSLNTYSNVVLDGPADTAALMVQ 431
                   .|.||..|:: ||:....:.::|    .||....|..|
  Rat   434 PLGSASVATRSPIEPSALEPAYYQESLWNN----RPASAEELTPQ 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	32/80 (40%)
Foxa1	XP_038967720.1	Forkhead_N	17..169	CDD:369872	11/51 (22%)
		FH_FOXA1	157..268	CDD:410812	43/137 (31%)
		HNF_C	393..457	CDD:430552	16/67 (24%)