DRSC/TRiP Functional Genomics Resources

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Protein Alignment foxo and FOXO3

DIOPT Version :10

Sequence 1:NP_650330.3 Gene:foxo / 41709 FlyBaseID:FBgn0038197 Length:622 Species:Drosophila melanogaster
Sequence 2:NP_001446.1 Gene:FOXO3 / 2309 HGNCID:3821 Length:673 Species:Homo sapiens


Alignment Length:698 Identity:227/698 - (32%)
Similarity:283/698 - (40%) Gaps:230/698 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 DLPLDVGFEPQTRARSNTWPCPRPENFVEPTDELDSTKA-------------------------- 65
            ::.||..||||:|.||.|||..|||....|......|.|                          
Human    15 EVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDEDGGGRAGSAMAI 79

  Fly    66 -----------------SNQQLAPGDSQQAIQNANAA---------------------------- 85
                             |.:.||||........|.||                            
Human    80 GGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLPPPQPGAAGGS 144

  Fly    86 ---KKNSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNS 147
               :|.|||||||||||||||||.||.|:.||||||||||||||:.|||||||||||||||||||
Human   145 GQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNS 209

  Fly   148 IRHNLSLHNRFMRVQNEGTGKSSWWMLNPE-AKPGKSVRRRAASMETS-RYEKRRGRAKKRVEAL 210
            ||||||||:||||||||||||||||::||: .|.||:.||||.||:.| :|.|.||||.|:..||
Human   210 IRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAAL 274

  Fly   211 RQAGVVGLNDATPSPSSSVSEGLDHFPESPL-HSGGGFQLSPDFRQRASSNASS-CGRLSPIRA- 272
            :.|.    ..|..|||.     |..:|.||. .|........|||.|.:||||: .||||||.| 
Human   275 QTAP----ESADDSPSQ-----LSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPIMAS 330

  Fly   273 ------QD---------------LEPDWGFPVDYQNTTMT-QAHAQAL-----EELTGTMADELT 310
                  ||               |.|....|...:...:| .|....|     |.|...:.|.:|
Human   331 TELDEVQDDDAPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLNDGLTENLMDDLLDNIT 395

  Fly   311 LCNQQQQGFSAASGLPSQPPPPPYQPPQHQQAQQQQQQQSPYALNG-----PASGYNT--LQPQS 368
            |             .||||.|        .....|:....||...|     |.|.:|:  ..|.|
Human   396 L-------------PPSQPSP--------TGGLMQRSSSFPYTTKGSGLGSPTSSFNSTVFGPSS 439

  Fly   369 QCLLHRSLNCSCMHN--------------------ARDGLSPNSVTTTMS-PAYPNSEPSSDSLN 412
            ...|.:|...:...|                    ..|.||.:.|..|.| |....:..:..:.|
Human   440 LNSLRQSPMQTIQENKPATFSSMSHYGNQTLQDLLTSDSLSHSDVMMTQSDPLMSQASTAVSAQN 504

  Fly   413 TYSNVVLD---------------------------------------------GPADTAALMVQQ 432
            :..||:|.                                             |.:::::|...:
Human   505 SRRNVMLRNDPMMSFAAQPNQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNMGLSESSSLGSAK 569

  Fly   433 QQQQ----QQQQQLSASLEDNNCASTLIGQCLEVLNNEAQP----IDEFNLENFPVGNLECNVEE 489
            .|||    |..|.||.||..::..||...  |.|:.:|..|    :|.||      |:|||::|.
Human   570 HQQQSPVSQSMQTLSDSLSGSSLYSTSAN--LPVMGHEKFPSDLDLDMFN------GSLECDMES 626

  Fly   490 LLQQEMSYGGLLDINIPLATVNTNLVNSSSGPLSISNISNLSNISSNS 537
            :::.|:.....||.|........|:|.     |::.|.:.....||.|
Human   627 IIRSELMDADGLDFNFDSLISTQNVVG-----LNVGNFTGAKQASSQS 669

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
foxoNP_650330.3 FH_FOXO 96..175 CDD:410806 70/78 (90%)
FOXO3NP_001446.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..153 28/137 (20%)
Required for mitochondrial import. /evidence=ECO:0000269|PubMed:23283301 80..108 5/27 (19%)
FH_FOXO3 157..239 CDD:410835 72/81 (89%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..302 35/79 (44%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:17940099, ECO:0000269|PubMed:29445193 242..259 10/16 (63%)
Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000269|PubMed:15084260 300..673 92/404 (23%)
FOXO_KIX_bdg 432..511 CDD:465228 15/78 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 536..587 9/50 (18%)
FOXO-TAD 606..644 CDD:435506 13/43 (30%)

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