| Sequence 1: | NP_001262557.1 | Gene: | foxo / 41709 | FlyBaseID: | FBgn0038197 | Length: | 622 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_002006.2 | Gene: | FOXO1 / 2308 | HGNCID: | 3819 | Length: | 655 | Species: | Homo sapiens |
| Alignment Length: | 681 | Identity: | 214/681 - (31%) |
|---|---|---|---|
| Similarity: | 281/681 - (41%) | Gaps: | 221/681 - (32%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 30 LDVGFEPQTRARSNTWPCPRPENFVEPTDELDSTKASNQQLAPGDSQQAIQNANAA--------- 85
Fly 86 ----------------------------------------------------------------- 85
Fly 86 ------------KKNSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDS 138
Fly 139 NSSAGWKNSIRHNLSLHNRFMRVQNEGTGKSSWWMLNPE-AKPGKSVRRRAASME-TSRYEKRRG 201
Fly 202 RAKKRVEALRQAGVVGLNDATPSPSSSVSEGLDHFPESP-LHSGGGFQLSPDFRQRASSNASS-C 264
Fly 265 GRLSPIRAQDLEPDWG--------FPVDYQNTTMTQAHAQALEELTG-----TMADELTLCN--- 313
Fly 314 --------------QQQQGFSAASGLPS-QPPPPPYQ----------PPQHQQAQQQQQQQSPYA 353
Fly 354 LNGPASGYN---------------------------TLQPQSQCLLHRSLNCSCMHNARDGLSPN 391
Fly 392 SVTTT----------MSPA---YP---------NSEPSSDSLNTYSNVVLDGPADTAALMVQQQQ 434
Fly 435 QQQQQQQLSASLEDNNCASTLIGQ-CLEVLNNEAQPIDEFNLENFPVGNLECNVEELLQQEMSYG 498
Fly 499 GLLDINIPLATVNTNLVNSSSGPLSISNISN 529 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| foxo | NP_001262557.1 | FH | 95..175 | CDD:238016 | 69/79 (87%) |
| FOXO1 | NP_002006.2 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..63 | 20/53 (38%) | |
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 116..158 | 4/41 (10%) | |||
| FH | 160..240 | CDD:238016 | 69/79 (87%) | ||
| DNA-binding | 211..218 | 6/6 (100%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 234..344 | 57/119 (48%) | |||
| DNA-binding | 234..237 | 2/2 (100%) | |||
| Nuclear localization signal | 251..253 | 1/1 (100%) | |||
| Sufficient for interaction with NLK. /evidence=ECO:0000250 | 283..563 | 69/307 (22%) | |||
| Required for interaction with RUNX2. /evidence=ECO:0000250 | 363..459 | 22/98 (22%) | |||
| FOXO_KIX_bdg | 423..500 | CDD:318810 | 13/90 (14%) | ||
| Required for interaction with SIRT1. /evidence=ECO:0000250 | 462..466 | 0/3 (0%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 507..537 | 4/29 (14%) | |||
| FOXO-TAD | 597..633 | CDD:318811 | 10/44 (23%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 155 | 1.000 | Domainoid score | I4214 |
| eggNOG | 1 | 0.900 | - | - | E2759_KOG2294 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 263 | 1.000 | Inparanoid score | I3087 |
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D1160384at2759 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0000837 | |
| OrthoInspector | 1 | 1.000 | - | - | otm41061 | |
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 1 | 1.100 | - | - | O | PTHR45767 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R4575 |
| SonicParanoid | 1 | 1.000 | - | - | X489 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 12 | 11.960 | |||||