Protein Alignment foxo and FOXS1

DIOPT Version :10

• Sequence 1: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_004109.1
• Gene: FOXS1 / 2307
• HGNCID: 3735
• Length: 330
• Species: Homo sapiens
• Alignment Length: 321
• Identity: 81/321 - (25%)
• Similarity: 120/321 - (37%)
• Gaps: 88/321 - (27%)

  Fly    99 SYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSIRHNLSLHNRFMRVQN 163
            ||..||..||.|:..:|.|||.||.:::....:::     ::..||:|||||||||:..|::|..
Human    22 SYIALIAMAIQSSPGQRATLSGIYRYIMGRFAFYR-----HNRPGWQNSIRHNLSLNECFVKVPR 81

  Fly   164 EG--TGKSSWWMLNPEA----KPGKSVRRRAASMETSRYEKRRGRAKKRVEALRQ---------- 212
            :.  .||.|:|.|:|:.    :.|..:|||......:..|..||.||.|...||.
Human    82 DDRKPGKGSYWTLDPDCHDMFEHGSFLRRRRRFTRQTGAEGTRGPAKARRGPLRATSQDPGVPNA 146

  Fly   213 --------------------AGVVGLNDATPSPSSSVSEGLDHFPESPLHSGGGFQLSPDFRQRA 257
                                .|:||...|:..|:::     |..|..|:..           :..
Human   147 TTGRQCSFPPELPDPKGLSFGGLVGAMPASMCPATT-----DGRPRPPMEP-----------KEI 195

  Fly   258 SSNASSC-GRLSPIRAQDLEPDWGFPVDYQNT-TMTQAHAQALEELTG------TMADELTLCNQ 314
            |:...:| |.|....:....|.:|||..:... :..:|....|...:|      .....|..|..
Human   196 STPKPACPGELPVATSSSSCPAFGFPAGFSEAESFNKAPTPVLSPESGIGSSYQCRLQALNFCMG 260

  Fly   315 QQQGFS--AASGLPS-QPPPPPYQ-------PPQHQQAQQQQQQQSPYALNG----PASGY 361
            ...|..  .||..|| .||.||..       |..|::         |:...|    ..|||
Human   261 ADPGLEHLLASAAPSPAPPTPPGSLRAPLPLPTDHKE---------PWVAGGFPVQGGSGY 312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	30/77 (39%)
FOXS1	NP_004109.1	FH_FOXS1	17..116	CDD:410811	36/98 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	111..157		9/45 (20%)
		PRK12323	<116..313	CDD:481241	45/222 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	179..200		5/36 (14%)