Protein Alignment foxo and FOXE1

DIOPT Version :10

• Sequence 1: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_004464.2
• Gene: FOXE1 / 2304
• HGNCID: 3806
• Length: 373
• Species: Homo sapiens
• Alignment Length: 351
• Identity: 87/351 - (24%)
• Similarity: 126/351 - (35%)
• Gaps: 114/351 - (32%)

  Fly    46 PCPRPENFVEPTDELDSTKASNQQLAPGDSQQAIQNANAAKKNSSRRNAWGNLSYADLITHAIGS 110
            |.|:||......:|...|.|...  .||::..  :.|...::....:......||..||..||..
Human     8 PPPQPEVLATVKEERGETAAGAG--VPGEATG--RGAGGRRRKRPLQRGKPPYSYIALIAMAIAH 68

  Fly   111 ATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSIRHNLSLHNRFMRVQNEG--TGKSSWWM 173
            |.::||||..||:::.:..|:::|     :...|:|||||||:|::.|:::..|.  .||.::|.
Human    69 APERRLTLGGIYKFITERFPFYRD-----NPKKWQNSIRHNLTLNDCFLKIPREAGRPGKGNYWA 128

  Fly   174 LNPEAKPGKSVRRRAASMETSRYEKRRGRAKK--------------------------------R 206
            |:|.|:.         ..|:..:.:||.|.|:                                .
Human   129 LDPNAED---------MFESGSFLRRRKRFKRSDLSTYPAYMHDAAAAAAAAAAAAAAAAIFPGA 184

  Fly   207 VEALR--QAGVVGLNDATPS---------PSSSVSE----GLDHFPESPLHSGGGFQLSPDFRQR 256
            |.|.|  ..|.|....|.||         |::|...    ||  .||.|        |||:....
Human   185 VPAARPPYPGAVYAGYAPPSLAAPPPVYYPAASPGPCRVFGL--VPERP--------LSPELGPA 239

  Fly   257 ASSNASSCGRLSPIRAQDLEPDWGFP---VDYQNTTMT-------QAHAQALEELTGTMADELTL 311
            .|....||...|.          |.|   ..||....|       .|:|.|.....|.
Human   240 PSGPGGSCAFASA----------GAPATTTGYQPAGCTGARPANPSAYAAAYAGPDGA------- 287

  Fly   312 CNQQQQG-----FSAASGL--PSQPP 330
               ..||     |:||..|  |:.||
Human   288 ---YPQGAGSAIFAAAGRLAGPASPP 310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	29/80 (36%)
FOXE1	NP_004464.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..51		6/35 (17%)
		FH_FOXE	53..141	CDD:410793	33/101 (33%)
		PRK07003	<182..>318	CDD:235906	40/159 (25%)