Protein Alignment foxo and FOXD4

DIOPT Version :10

• Sequence 1: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_997188.2
• Gene: FOXD4 / 2298
• HGNCID: 3805
• Length: 439
• Species: Homo sapiens
• Alignment Length: 593
• Identity: 125/593 - (21%)
• Similarity: 180/593 - (30%)
• Gaps: 244/593 - (41%)

  Fly    11 RLTHTDNGLAMDQLGGDLPLDVGFEPQTRARSNTWPCPRPENFVEPTDELDSTKASNQQLAPGDS 75
            ||..|......|..|.|..:||                    ..|..|| |..:|::||......
Human     8 RLRSTPQRSLRDSDGEDGKIDV--------------------LGEEEDE-DEEEAASQQFLEQSL 51

  Fly    76 QQAIQNA---------------------------------NAAKKNSSRRNAWGNLSYADLITHA 107
            |..:|.|                                 :||....:|:.|....||..|||.|
Human    52 QPGLQVARWGGVALPREHIEGGGGPSDPSEFGTEFRAPPRSAAASEDARQPAKPPSSYIALITMA 116

  Fly   108 IGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSIRHNLSLHNRFMRVQNE--GTGKSS 170
            |..:..||||||.|..::....||::.|     ...|:|||||||||::.|:::..|  ..||.:
Human   117 ILQSPHKRLTLSGICAFISDRFPYYRRK-----FPAWQNSIRHNLSLNDCFVKIPREPGRPGKGN 176

  Fly   171 WWMLNPEAKP----GKSVRRRAASMETSRYEKRRGRAKKRVEALRQAGVVGLNDATPSPSSSVSE 231
            :|.|:|.::.    |..:|||      .|:::.:                      |:|.:
Human   177 YWSLDPASQDMFDNGSFLRRR------KRFQRHQ----------------------PTPGA---- 209

  Fly   232 GLDHFPESPLHSGGGFQLSPDFRQRASSNASSCGRLSPIRAQDLEPDWGFPVDYQNTTMTQAHAQ 296
               |.|..                                         ||       :..|||.
Human   210 ---HLPHP-----------------------------------------FP-------LPAAHAA 223

  Fly   297 ALEELTGTMADELTLCNQQQQGFSAASGLPSQPPPPPYQPPQHQQAQQQQQQQSPYALNGP---- 357
            ......|.:.                 |.|:.|.|.|...|.....::      ||||..|
Human   224 LHNPRPGPLL-----------------GAPAPPQPVPGAYPNTGPGRR------PYALLHPHPPR 265

  Fly   358 ---------------ASGYN--TLQPQSQCLLHRSLNCSCMHNARDGLSPNSVTTTMSPAYPNSE 405
                           |.|.:  |..|...|..|  |..|....||..........::|....:.:
Human   266 YLLLSAPAYAGAPKKAEGADLATPAPFPCCSPH--LVLSLGRRARVWRRHREADASLSALRVSCK 328

  Fly   406 PSSDSLNTYSNVVLDGPADTAALMVQQQ------QQQQQQQQLSASLED--NNCAST---LIGQC 459
            .|.:.:.....|.......||.....:|      ||||:.|:     ||  |.||.|   ::|
Human   329 GSGERVQGLRRVCPRPRGATAPCSSDRQACRTILQQQQRHQE-----EDCANGCAPTKGAVLG-- 386

  Fly   460 LEVLNNEAQPIDEFNLENFPVGNLECNVEELLQQEMSYG-GLLDINIPLATVNTN---LVN---- 516
                                 |:|......|..|.::.| ||..:..||....|:   ||:
Human   387 ---------------------GHLSAASALLRYQAVAEGSGLTSLAAPLGGEGTSPVFLVSPTPS 430

  Fly   517 ---SSSGP 521
               .|:||
Human   431 SLAESAGP 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	32/80 (40%)
FOXD4	NP_997188.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46		14/58 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	62..104		3/41 (7%)
		FH_FOXD4-like	104..199	CDD:410822	38/105 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	204..232		10/104 (10%)