Protein Alignment foxo and FOXC1

DIOPT Version :10

• Sequence 1: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_001444.2
• Gene: FOXC1 / 2296
• HGNCID: 3800
• Length: 553
• Species: Homo sapiens
• Alignment Length: 630
• Identity: 142/630 - (22%)
• Similarity: 215/630 - (34%)
• Gaps: 204/630 - (32%)

  Fly    29 PLDVGFEP---------QTRARSNTWPCPRPENFVEPTDELDSTKASNQQLAPGDSQQAIQNANA 84
            |:.|...|         ..||.....|.|:|::.|:|.
Human    43 PMSVYSHPAHAEQYPGGMARAYGPYTPQPQPKDMVKPP--------------------------- 80

  Fly    85 AKKNSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSIR 149
                         .||..|||.||.:|.||::||:.||::::...|:::|     :..||:||||
Human    81 -------------YSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRD-----NKQGWQNSIR 127

  Fly   150 HNLSLHNRFMRV--QNEGTGKSSWWMLNPEA----KPGKSVRRRAASMETSRYEKRRGRAKKRVE 208
            |||||:..|::|  .::..||.|:|.|:|::    :.|..:|||       |..|::...|.:.|
Human   128 HNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRR-------RRFKKKDAVKDKEE 185

  Fly   209 ALRQAGVVGLNDATPSPSSSVSEGLDHFPESPLHSGGGFQLSPDFRQRASSNASSCGRLSPIRAQ 273
            ..|.                      |..|.|   ..|.|..|...::|..||.. .:..|:|.|
Human   186 KDRL----------------------HLKEPP---PPGRQPPPAPPEQADGNAPG-PQPPPVRIQ 224

  Fly   274 DLEPDWG-FPVDYQNTTMTQA----HAQALEELTGTMADELTLCNQQQQGFSAASGLPS------ 327
            |::.:.| .|...|..:...|    .|.|:.::....:...:|    ..|.|....|||
Human   225 DIKTENGTCPSPPQPLSPAAALGSGSAAAVPKIESPDSSSSSL----SSGSSPPGSLPSARPLSL 285

  Fly   328 ------QPPPPPYQPPQHQQAQQQQQQQSPYALNGPASGYNTLQPQSQCL-LHRSLNCSCMHNAR 385
                  .|||.|..||.| .:|.........:|.|        .|||... |...|..|...::|
Human   286 DGADSAPPPPAPSAPPPH-HSQGFSVDNIMTSLRG--------SPQSAAAELSSGLLASAAASSR 341

  Fly   386 DGLSPNSVTTTMSPAYPN--SEPSSDSLNTYSNVVLDGPADTAALMVQQQQQQQQQQQLSASLED 448
            .|::|.......||...:  |.|.|.:.:..|:....|.|..|.               .|.
Human   342 AGIAPPLALGAYSPGQSSLYSSPCSQTSSAGSSGGGGGGAGAAG---------------GAG--- 388

  Fly   449 NNCASTLIGQCLEVLNNEAQPIDEFNLENFPVGNLECNVEEL-LQQEMSYGGLLDINIP----LA 508
                                          ..|...||::.: |......||.|. ..|    .:
Human   389 ------------------------------GAGTYHCNLQAMSLYAAGERGGHLQ-GAPGGAGGS 422

  Fly   509 TVNTNLVNSSSGPLSISNISNLSNISSNSG------------------SSLSLNQLQAQLQQQQQ 555
            .|:..|.:.|..|::.|:.|:||:.....|                  :|..|||....|.....
Human   423 AVDDPLPDYSLPPVTSSSSSSLSHGGGGGGGGGGQEAGHHPAAHQGRLTSWYLNQAGGDLGHLAS 487

  Fly   556 QQQAQQQQQAQQQQQQHQQ-----HQQQLLLNNNN-NSSSSLELA 594
            ...|........|||....     ..|::.|||:. |.:||.::|
Human   488 AAAAAAAAGYPGQQQNFHSVREMFESQRIGLNNSPVNGNSSCQMA 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	33/80 (41%)
FOXC1	NP_001444.2	Required for transcriptional activation. /evidence=ECO:0000269|PubMed:11782474	1..51		2/7 (29%)
		FH_FOXC1	73..165	CDD:410818	38/136 (28%)
		Nuclear localization signal 1 (NLS 1). /evidence=ECO:0000269|PubMed:11782474	78..93		8/54 (15%)
		Nuclear localization signal 2 (NLS 2). /evidence=ECO:0000269|PubMed:11782474	168..176		4/14 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	173..310		37/167 (22%)
		Required for transcriptional inhibition. /evidence=ECO:0000269|PubMed:11782474	215..366		39/164 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	356..387		7/45 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	414..465		10/50 (20%)
		Required for transcriptional activation. /evidence=ECO:0000269|PubMed:11782474	466..553		17/67 (25%)