Protein Alignment foxo and FOXF2

DIOPT Version :10

• Sequence 1: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_001443.1
• Gene: FOXF2 / 2295
• HGNCID: 3810
• Length: 444
• Species: Homo sapiens
• Alignment Length: 403
• Identity: 99/403 - (24%)
• Similarity: 150/403 - (37%)
• Gaps: 146/403 - (36%)

  Fly    62 STKASNQQLAPGDSQQAIQNANA------AKKNSS--RRNAWGNLSYADLITHAIGSATDKRLTL 118
            |:.:||...||..:.::.....|      |||.||  ||......||..||..||.|:..|||||
Human    59 SSSSSNSASAPSAACKSAGGGGAGAGSGGAKKASSGLRRPEKPPYSYIALIVMAIQSSPSKRLTL 123

  Fly   119 SQIYEWMVQNVPYFKDKGDSNSSAGWKNSIRHNLSLHNRFMRVQNEG---TGKSSWWMLNPEAKP 180
            |:||:::....|:|:     .:..|||||:||||||:..|:::. :|   .||..:|.::|.::
Human   124 SEIYQFLQARFPFFR-----GAYQGWKNSVRHNLSLNECFIKLP-KGLGRPGKGHYWTIDPASE- 181

  Fly   181 GKSVRRRAASMETSRYEKRRGRAKKRVEALR---QAGVVGLNDATPSPSSSVSEGLDHF--PESP 240
                    ...|...:.:|....:::.:||:   ...|.||...    :|.:.:|.|..  |.:|
Human   182 --------FMFEEGSFRRRPRGFRRKCQALKPMYHRVVSGLGFG----ASLLPQGFDFQAPPSAP 234

  Fly   241 L--HSGGGF-------------------------------QLSPDFRQRASSNASSCGRLSPIRA 272
            |  ||.||:                               .:||:   ..|:..:||    |:.|
Human   235 LGCHSQGGYGGLDMMPAGYDAGAGAPSHAHPHHHHHHHVPHMSPN---PGSTYMASC----PVPA 292

  Fly   273 -------------QDLEPDWGFPVDYQNTTMTQAHAQALEELTGTMADELTLCNQQQQGFSAASG 324
                         .|..||                                         |::|.
Human   293 GPGGVGAAGGGGGGDYGPD-----------------------------------------SSSSP 316

  Fly   325 LPSQPP-------PPPYQPPQHQQAQQQQQQQSPYALNGPASGYNTLQPQSQCLLHRSLNC---- 378
            :||.|.       ..||..|   .|.......|||....||...:: .|.:...||.|::.
Human   317 VPSSPAMASAIECHSPYTSP---AAHWSSPGASPYLKQPPALTPSS-NPAASAGLHSSMSSYSLE 377

  Fly   379 -SCMH-NARDGLS 389
             |.:| |||:.||
Human   378 QSYLHQNAREDLS 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	33/81 (41%)
FOXF2	NP_001443.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	32..98		12/38 (32%)
		FH_FOXF1	101..199	CDD:410823	36/112 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	256..323		15/114 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	338..367		7/29 (24%)