Protein Alignment foxo and Foxd2

DIOPT Version :10

• Sequence 1: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_032619.1
• Gene: Foxd2 / 17301
• MGIID: 1347471
• Length: 492
• Species: Mus musculus
• Alignment Length: 450
• Identity: 103/450 - (22%)
• Similarity: 160/450 - (35%)
• Gaps: 149/450 - (33%)

  Fly    25 GGDLPLDVGFEPQTRARSNTWPCPR---PENFVEPTDELDSTKASNQQ------------LA--- 71
            ||:|          .|||.. ..||   |.....|.:|.::..|.:::            ||
Mouse    36 GGEL----------TARSGP-RAPRDVLPHGHEPPPEEAEADVAEDEEESGGCSDCEPRALAPRG 89

  Fly    72 -------PGDSQQAIQNA------------NAAKKNSSRRNAWGNLSYADLITHAIGSATDKRLT 117
                   ||...||.:.|            .||.::...:..:   ||..|||.||..:..||||
Mouse    90 AAAAAGSPGPGVQAARGATGPGPGPGPPSGGAATRSPLVKPPY---SYIALITMAILQSPKKRLT 151

  Fly   118 LSQIYEWMVQNVPYFKDKGDSNSSAGWKNSIRHNLSLHNRFMRVQNE--GTGKSSWWMLNPEAKP 180
            ||:|.|::....||:::|     ...|:|||||||||::.|:::..|  ..||.::|.|:||:
Mouse   152 LSEICEFISGRFPYYREK-----FPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPES-- 209

  Fly   181 GKSVRRRAASMETSRYEKRRGRAKKR------------VEALRQAGVVGLNDATPSPSSSVSEGL 233
                   |...:...:.:||.|.|::            .|.|.:.|.....|.....||..:.|.
Mouse   210 -------ADMFDNGSFLRRRKRFKRQPLPPPHPHPHPHPELLLRGGAAAAGDPGAFLSSFAAYGA 267

  Fly   234 DHFPESPLHSGGGFQLS----------------PDFRQRASSNASSCGRLSPIRAQDLEPDWGFP 282
                     .|.|:.|:                |.....|.:..:.| :||....:...|..|.|
Mouse   268 ---------YGYGYGLALPAYGAPPPGPAPHPHPHPHAFAFAATAPC-QLSVPPGRAAAPPPGPP 322

  Fly   283 VDYQNTTMTQAHAQALEELTGTMADELTLCNQQQQGFSAASGLPSQPPPPPYQP-----PQHQQA 342
                               |.::             |::|:..|:..|.|...|     |....|
Mouse   323 -------------------TASV-------------FASAASAPAPAPAPGSGPSPAGLPAFLGA 355

  Fly   343 QQQ-QQQQSPYALNGPASGYNTLQPQSQCLLHRSLNCSCMHNARDGLSPNSVTTTMSPAY 401
            :.. .:...|.:|:.||:|  |....|..||.:.|..    :|..|.......|...|::
Mouse   356 ELGCAKAFYPASLSPPAAG--TAASLSTALLRQGLKT----DAGGGAGGGGAGTGQRPSF 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	33/80 (41%)
Foxd2	NP_032619.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	13..125		21/99 (21%)
		FH_FOXD1_D2-like	129..227	CDD:410820	40/114 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	309..344		9/66 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	394..441		3/15 (20%)