Protein Alignment foxo and Foxc1

DIOPT Version :10

• Sequence 1: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_032618.2
• Gene: Foxc1 / 17300
• MGIID: 1347466
• Length: 553
• Species: Mus musculus
• Alignment Length: 617
• Identity: 139/617 - (22%)
• Similarity: 217/617 - (35%)
• Gaps: 178/617 - (28%)

  Fly    29 PLDVGFEP---------QTRARSNTWPCPRPENFVEPTDELDSTKASNQQLAPGDSQQAIQNANA 84
            |:.|...|         ..||.....|.|:|::.|:|.
Mouse    43 PMSVYSHPAHAEQYPGSMARAYGPYTPQPQPKDMVKPP--------------------------- 80

  Fly    85 AKKNSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSIR 149
                         .||..|||.||.:|.||::||:.||::::...|:::|     :..||:||||
Mouse    81 -------------YSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRD-----NKQGWQNSIR 127

  Fly   150 HNLSLHNRFMRV--QNEGTGKSSWWMLNPEA----KPGKSVRRRAASMETSRYEKRRGRAKKRVE 208
            |||||:..|::|  .::..||.|:|.|:|::    :.|..:|||           ||.:.|..|:
Mouse   128 HNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRR-----------RRFKKKDAVK 181

  Fly   209 ALRQAGVVGLNDATPSPSSSVSEGLDHFPESPLHSGGGFQLSPDFRQRASSNASSCGRLSPIRAQ 273
            ...:.|.:.|.:..|             |::      |.|.:|...::|..:|.. .:..|:|.|
Mouse   182 DKEEKGRLHLQEPPP-------------PQA------GRQPAPAPPEQAEGSAPG-PQPPPVRIQ 226

  Fly   274 DLEPDWG-FPVDYQNTTMTQAHAQALEELTGTMADELTLCNQQQQGFSAASGLPS---------- 327
            |::.:.| .|...|..:...|...........:....:..:....|.|....|||
Mouse   227 DIKTENGTCPSPPQPLSPAAALGSGSAATVPKIESPDSSSSSLSSGSSPPGSLPSARPLSLDAAE 291

  Fly   328 -QPPPPPYQPPQHQQAQQQQQQQSPYALNGPASGYNTLQPQSQCLLHRSLNCSCMHNARDGLSPN 391
             .|||.|..||.|.|........:  :|.|...|       |...|...|..|...::|.|::|.
Mouse   292 PAPPPQPAPPPHHSQGFSVDNIMT--SLRGSPQG-------SAAELGSGLLASAAASSRAGIAPP 347

  Fly   392 SVTTTMSPAYPN--SEPSSDSLNTYSNVVLDGPADTAALMVQQQQQQQQQQQLSASLEDNNCAST 454
            ......||...:  |.|.|.|.:..|:....|......              .|:|......|:|
Mouse   348 LALGAYSPGQSSLYSSPCSQSSSAGSSGGGGGGGGGGG--------------GSSSAAGTGGAAT 398

  Fly   455 LIGQCLEVLNNEAQPIDEFNLENFPVGNLECNVEEL-LQQEMSYGGLLD---INIPLATVNTNLV 515
                                        ..||::.: |......||.|.   .....|.|:..|.
Mouse   399 ----------------------------YHCNLQAMSLYAAGERGGHLQGPAGGAGSAAVDDPLP 435

  Fly   516 NSSSGPLSISNISNLS----------NISSNSG--SSLSLNQLQAQLQQQQQQQQAQQQQQAQQQ 568
            :.|..|.:.|:.|:||          :.:|:.|  :|..|||....|........|........|
Mouse   436 DYSLPPATSSSSSSLSHGGGGQEASHHPASHQGRLTSWYLNQAGGDLGHLASAAAAAAAAGYPGQ 500

  Fly   569 QQQHQQ-----HQQQLLLNNNN-NSSSSLELA 594
            ||....     ..|::.|||:. |.:||.::|
Mouse   501 QQNFHSVREMFESQRIGLNNSPVNGNSSCQMA 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	33/80 (41%)
Foxc1	NP_032618.2	Required for transcriptional activation. /evidence=ECO:0000250|UniProtKB:Q12948	1..51		2/7 (29%)
		FH_FOXC1	73..165	CDD:410818	38/136 (28%)
		Nuclear localization signal 1 (NLS 1). /evidence=ECO:0000250|UniProtKB:Q12948	78..93		8/54 (15%)
		Nuclear localization signal 2 (NLS 2). /evidence=ECO:0000250|UniProtKB:Q12948	168..176		5/18 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	173..326		37/181 (20%)
		Required for transcriptional inhibition. /evidence=ECO:0000250|UniProtKB:Q12948	217..366		35/158 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	356..393		8/50 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	420..466		9/45 (20%)
		Required for transcriptional activation. /evidence=ECO:0000250|UniProtKB:Q12948	466..553		18/67 (27%)