Protein Alignment foxo and daf-16

DIOPT Version :9

• Sequence 1: NP_001262557.1
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_001367893.1
• Gene: daf-16 / 172981
• WormBaseID: WBGene00000912
• Length: 541
• Species: Caenorhabditis elegans
• Alignment Length: 488
• Identity: 157/488 - (32%)
• Similarity: 227/488 - (46%)
• Gaps: 136/488 - (27%)

  Fly    66 SNQQLAPGD--SQQAIQNANAAKKNSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQN 128
            |:|...|.|  ..::..:..:.||.::|||||||:|||:|||.||.::.:|||||:|:|||||||
 Worm   144 SHQTSFPSDFRMSESPDDTVSGKKTTTRRNAWGNMSYAELITTAIMASPEKRLTLAQVYEWMVQN 208

  Fly   129 VPYFKDKGDSNSSAGWKNSIRHNLSLHNRFMRVQNEGTGKSSWWMLNPEAKPGKSVRR---RAAS 190
            ||||:||||||||||||||||||||||:||||:||||.||||||::||:||||::.||   |:.:
 Worm   209 VPYFRDKGDSNSSAGWKNSIRHNLSLHSRFMRIQNEGAGKSSWWVINPDAKPGRNPRRTRERSNT 273

  Fly   191 MET---SRYEKRRGRAKKRVEALRQAGVVGLNDATPSPSS------SVSEGLDHFPESPLHSGGG 246
            :||   ::.||.|..||||:   ::..::|...:|.:.:|      ::|.  |.:.:..:.  |.
 Worm   274 IETTTKAQLEKSRRGAKKRI---KERALMGSLHSTLNGNSIAGSIQTISH--DLYDDDSMQ--GA 331

  Fly   247 FQLSP-DFRQRASSNAS---SCGRLSPIRAQDLE-----PDW------GFPVDYQNTTMTQAHAQ 296
            |...| .||.|..||.|   |..|:||....|:.     |.|      ..|.|..:.| .|....
 Worm   332 FDNVPSSFRPRTQSNLSIPGSSSRVSPAIGSDIYDDLEFPSWVGESVPAIPSDIVDRT-DQMRID 395

  Fly   297 ALEELTGTMADELTLCNQQQQGFSAASGLPSQP--PPPPYQPPQHQQAQQQQQQQSPYALNGPAS 359
            |...:.|....:            .:..:.::|  |||.|                 :.||
 Worm   396 ATTHIGGVQIKQ------------ESKPIKTEPIAPPPSY-----------------HELN---- 427

  Fly   360 GYNTLQPQSQCLLHRSLNCSCMHN--ARDGLSPNSVTTTMSP-----AYPNSEPSS----DSLNT 413
                           |:..||..|  .|:.:.|   :|...|     ||.|.:...    :.|:|
 Worm   428 ---------------SVRGSCAQNPLLRNPIVP---STNFKPMPLPGAYGNYQNGGITPINWLST 474

  Fly   414 YSNVVLDGPADTAALMVQQQQQQQQQQQLSASLEDNNCASTLIGQCLEVLNNEAQPIDEFNLENF 478
            .::..|.|......:..|.                            .|.::.|.|||   |||.
 Worm   475 SNSSPLPGIQSCGIVAAQH----------------------------TVASSSALPID---LENL 508

  Fly   479 PVGNL----ECNVEELLQQEMSYGGLLDINIPL 507
            .:.:.    ..:|:.|::.|:|..|...|:..|
 Worm   509 TLPDQPLMDTMDVDALIRHELSQAGGQHIHFDL 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_001262557.1	FH	95..175	CDD:238016	64/79 (81%)
daf-16	NP_001367893.1	FH_FOXO	176..255	CDD:410806	63/78 (81%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158216
Domainoid	1	1.000	151	1.000	Domainoid score	I2686
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1160384at2759
OrthoFinder	1	1.000	-	-		FOG0000837
OrthoInspector	1	1.000	-	-		oto18640
orthoMCL	1	0.900	-	-		OOG6_108778
Panther	1	1.100	-	-	LDO	PTHR45767
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4575
SonicParanoid	1	1.000	-	-		X489
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.880