Protein Alignment foxo and Foxa2

DIOPT Version :10

• Sequence 1: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_001277994.1
• Gene: Foxa2 / 15376
• MGIID: 1347476
• Length: 465
• Species: Mus musculus
• Alignment Length: 321
• Identity: 81/321 - (25%)
• Similarity: 131/321 - (40%)
• Gaps: 76/321 - (23%)

  Fly    65 ASNQQLAPGDSQQAIQNANAAKK-NSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQN 128
            |:...::|...|..:..|...|. ..|..:|....||..|||.||..:.:|.||||:||:|::..
Mouse   134 ANMNSMSPMYGQAGLSRARDPKTYRRSYTHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDL 198

  Fly   129 VPYFKDKGDSNSSAGWKNSIRHNLSLHNRFMRVQN--EGTGKSSWWMLNPEA----KPGKSVRRR 187
            .|:::     .:...|:|||||:||.::.|::|..  :..||.|:|.|:|::    :.|..:||
Mouse   199 FPFYR-----QNQQRWQNSIRHSLSFNDCFLKVPRSPDKPGKGSFWTLHPDSGNMFENGCYLRR- 257

  Fly   188 AASMETSRYEKRRGRAKKRVEALRQAGVVGLNDATPSPSSSVSEGLDHFPESPLHSGGGFQLSPD 252
                      ::|.:.:|::.....||.........:|.|..|       ::.|....|
Mouse   258 ----------QKRFKCEKQLALKEAAGAASSGGKKTAPGSQAS-------QAQLGEAAG------ 299

  Fly   253 FRQRASSNASSCGRLSPIRAQDLEPDWGFPVDYQNTTMTQAHAQ-ALEELTGTMADELT------ 310
                 |::.:..|..||               :.:.:..|.|.: .|.||.|..|..|:
Mouse   300 -----SASETPAGTESP---------------HSSASPCQEHKRGGLSELKGAPASALSPPEPAP 344

  Fly   311 LCNQQQQGFSAASGLPSQP--PPPPYQPPQHQQAQQQQQQQSPYALNGPASGYNTLQPQSQ 369
            ...||||..:...|.|..|  ||..:..|:|.           ||.|.|.|..|.:..:.|
Mouse   345 SPGQQQQAAAHLLGPPHHPGLPPEAHLKPEHH-----------YAFNHPFSINNLMSSEQQ 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	30/80 (38%)
Foxa2	NP_001277994.1	Forkhead_N	23..164	CDD:369872	6/29 (21%)
		FH_FOXA2	163..264	CDD:410813	37/116 (32%)
		PRK07764	<266..>354	CDD:236090	23/120 (19%)
		HNF_C	380..454	CDD:430552	5/15 (33%)