Protein Alignment foxo and Foxa1

DIOPT Version :10

• Sequence 1: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_032285.2
• Gene: Foxa1 / 15375
• MGIID: 1347472
• Length: 468
• Species: Mus musculus
• Alignment Length: 418
• Identity: 100/418 - (23%)
• Similarity: 155/418 - (37%)
• Gaps: 107/418 - (25%)

  Fly    33 GFEPQTRARSNTWPCPRPENFVEPTDELDSTKASNQQLAPGDSQQAIQNANAAKKNSSRRNAWGN 97
            |..|...|.:   ||..|..:. |:: |..::|.    ..||::...::...||.         .
Mouse   126 GLGPYAAAMN---PCMSPMAYA-PSN-LGRSRAG----GGGDAKTFKRSYPHAKP---------P 172

  Fly    98 LSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSIRHNLSLHNRFMRVQ 162
            .||..|||.||..|..|.||||:||:|::...||::     .:...|:|||||:||.::.|::|.
Mouse   173 YSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYR-----QNQQRWQNSIRHSLSFNDCFVKVA 232

  Fly   163 N--EGTGKSSWWMLNPEAKPGKSVRRRAASMETSRYEKRRGRAKKRVEALRQAGVVGLNDATPSP 225
            .  :..||.|:|.|:|::         ....|...|.:|    :||.:..:|.|..|.:
Mouse   233 RSPDKPGKGSYWTLHPDS---------GNMFENGCYLRR----QKRFKCEKQPGAGGGS------ 278

  Fly   226 SSSVSEGLDHFPESPLHSGGGFQLSPDFRQRASSNASSCGRLSPI------RAQDLEPDWGFP-- 282
                             .|||.:..|:.|:..|...:.... ||:      :|..||   |.|
Mouse   279 -----------------GGGGSKGGPESRKDPSGPGNPSAE-SPLHRGVHGKASQLE---GAPAP 322

  Fly   283 --------VDYQNTTMTQAHAQALEELTGTMADELTLCNQQQQGFSAASGLPSQPPPPPYQPPQH 339
                    :|:...|.| ..|..|:....:.|..::         |....|.|.||..|......
Mouse   323 GPAASPQTLDHSGATAT-GGASELKSPASSSAPPIS---------SGPGALASVPPSHPAHGLAP 377

  Fly   340 QQAQQQQQQQSPYALNGPASGYNTLQPQSQCLLHRSLNCSCMHNARDGLSPNSVT---------- 394
            .::|...:....|:.|.|.|..|.:....|   ...|:......|.. .||...|
Mouse   378 HESQLHLKGDPHYSFNHPFSINNLMSSSEQ---QHKLDFKAYEQALQ-YSPYGATLPASLPLGSA 438

  Fly   395 --TTMSPAYPNSEPSSDSLNTYSNVVLD 420
              .|.||..|::...:.....||..||:
Mouse   439 SVATRSPIEPSALEPAYYQGVYSRPVLN 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	32/80 (40%)
Foxa1	NP_032285.2	Forkhead_N	17..169	CDD:369872	11/51 (22%)
		FH_FOXA1	157..268	CDD:410812	43/137 (31%)
		Essential for DNA binding	251..288		11/63 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	269..396		31/163 (19%)
		HNF_C	393..457	CDD:430552	14/67 (21%)