Protein Alignment foxo and Foxg1

DIOPT Version :10

• Sequence 1: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_032267.1
• Gene: Foxg1 / 15228
• MGIID: 1347464
• Length: 481
• Species: Mus musculus
• Alignment Length: 465
• Identity: 115/465 - (24%)
• Similarity: 174/465 - (37%)
• Gaps: 143/465 - (30%)

  Fly    36 PQTRARSNTWPCPRPEN----------------FVEPTDELDSTKA-----------SNQQLAPG 73
            |..:.:....|.|:|..                .:.|:..||..||           ...:|||.
Mouse    68 PPQQQQQQPPPAPQPPQARGAPAADDDKGPQPLLLPPSTALDGAKADALGAKGEPGGGPAELAPV 132

  Fly    74 DSQQAIQNANAA---KKNSSRRNAWGN----------------LSYADLITHAIGSATDKRLTLS 119
            ...:..:.|.|.   ||.:......|.                .||..||..||..:.:|||||:
Mouse   133 GPDEKEKGAGAGGEEKKGAGEGGKDGEGGKEGDKKNGKYEKPPFSYNALIMMAIRQSPEKRLTLN 197

  Fly   120 QIYEWMVQNVPYFKDKGDSNSSAGWKNSIRHNLSLHNRFMRVQN--EGTGKSSWWMLNPEA---- 178
            .|||::::|.||:::     :..||:|||||||||:..|::|..  :..||.::|||:|.:
Mouse   198 GIYEFIMKNFPYYRE-----NKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDPSSDDVF 257

  Fly   179 ---KPGKSVRRRAASMETSRYEKRRGRAKKRVEALRQAGVVGLNDATPSPSSSVSEGLDHFPESP 240
               ..|| :|||:.   |||.:    .|.||...|...|:..::.|          |..::|.||
Mouse   258 IGGTTGK-LRRRST---TSRAK----LAFKRGARLTSTGLTFMDRA----------GSLYWPMSP 304

  Fly   241 ---LHSGGGFQLSPDFRQRASSNASSCGRLSPIRAQDLEPDWGFPVDYQNTTMTQAHAQALEELT 302
               ||           ..||||..|..|..|...:.        |:.| ::.:||.
Mouse   305 FLSLH-----------HPRASSTLSYNGTTSAYPSH--------PMPY-SSVLTQN--------- 340

  Fly   303 GTMADELTLCNQQQQGFSAASGLPSQ---PPPPPYQPPQHQQAQQQQQQQSPYALNGPASGYNTL 364
                   :|.|  ...||.|:||...   ....||  ..|...........|..|:.|.||..:|
Mouse   341 -------SLGN--NHSFSTANGLSVDRLVNGEIPY--ATHHLTAAALAASVPCGLSVPCSGTYSL 394

  Fly   365 QPQSQCLL------------HRSLNCSCMHNARDGLSPNSVTTTMSPAYPNSEPSSD---SLNTY 414
            .|.|..||            |.|:.    ......:|..:.:::.||..|::.|...   ||.::
Mouse   395 NPCSVNLLAGQTSYFFPHVPHPSMT----SQTSTSMSARAASSSTSPQAPSTLPCESLRPSLPSF 455

  Fly   415 SNVVLDGPAD 424
            :..:..|.:|
Mouse   456 TTGLSGGLSD 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	35/96 (36%)
Foxg1	NP_032267.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	31..173		17/104 (16%)
		FH_FOXG	173..251	CDD:410795	35/82 (43%)
		COG5025	<176..>348	CDD:227358	69/232 (30%)
		Required for interaction with TLE6. /evidence=ECO:0000269|PubMed:16314515	241..336		35/132 (27%)
		Interaction with KDM5B. /evidence=ECO:0000250	375..398		7/22 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	419..447		5/31 (16%)