Protein Alignment foxo and FOXO6

DIOPT Version :9

• Sequence 1: NP_001262557.1
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_001278210.2
• Gene: FOXO6 / 100132074
• HGNCID: 24814
• Length: 559
• Species: Homo sapiens
• Alignment Length: 619
• Identity: 188/619 - (30%)
• Similarity: 244/619 - (39%)
• Gaps: 232/619 - (37%)

  Fly    30 LDVGFEPQTRARSNTWPCPRPENFVEPTDELDSTKASNQQLAPGDSQQAIQNANA---------- 84
            :|..|.||:|.||.|||.|:|:...:....|.:..|...:.. |..::|...|.|
Human    12 VDPDFAPQSRPRSCTWPLPQPDLAGDEDGALGAGVAEGAEDC-GPERRATAPAMAPAPPLGAEVG 75

  Fly    85 --AKKNSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNS 147
              .|..|||||||||||||||||.||.||.||||||||||:|||:.|||||||||||||||||||
Human    76 PLRKAKSSRRNAWGNLSYADLITKAIESAPDKRLTLSQIYDWMVRYVPYFKDKGDSNSSAGWKNS 140

  Fly   148 IRHNLSLHNRFMRVQNEGTGKSSWWMLNPE-AKPGKSVRRRAASMET-SRYEKRRGRAKKRVEAL 210
            ||||||||.||:|||||||||||||||||| .|.||:.||||.||:. :::.:.:|:|.|:.:.
Human   141 IRHNLSLHTRFIRVQNEGTGKSSWWMLNPEGGKTGKTPRRRAVSMDNGAKFLRIKGKASKKKQL- 204

  Fly   211 RQAGVVGLNDATP----------------SPSSSVSEGLDHF----------------------- 236
             ||.....:|::|                ||:|..|:..:.:
Human   205 -QAPERSPDDSSPSAPAPGPVPAAAKWAASPASHASDDYEAWADFRGGGRPLLGEAAELEDDEAL 268

  Fly   237 ----PESP---------------------------------LHSGGGFQLSPDF----------R 254
                |.||                                 ||.|||..|....          |
Human   269 EALAPSSPLMYPSPASALSPALGSRCPGELPRLAELGGPLGLHGGGGAGLPEGLLDGAQDAYGPR 333

  Fly   255 QRASSNA--SSC--------GRLSPIRAQDLEPDWGFPVDYQNTTMTQAHAQALEELTGTMADEL 309
            .||.:.|  ..|        |...|       |..|        .:.:...|.::|
Human   334 ARAGTPAYFGGCKGGAYGGGGGFGP-------PAMG--------ALRRLPMQTIQE--------- 374

  Fly   310 TLCNQQQQGFSAAS-----GLPSQPPPPPYQPPQHQQAQQQQQQQSP-------YALNGPASGYN 362
               |:|.....||:     .||:..||||..|           :..|       .||.|.|:.|
Human   375 ---NKQASFVPAAAPFRPGALPALLPPPPPAP-----------RPGPVLGAPGELALAGAAAAY- 424

  Fly   363 TLQPQSQCLLHRSLNCSCMHNARDGLSPNSVTTTMSPAYPNSEPSSDSL-NTYSNVVLDGPADTA 426
                                 ...|.:|          |....||..:| :..|.:.|.|.|.
Human   425 ---------------------PGKGAAP----------YAPPAPSRSALAHPISLMTLPGEAG-- 456

  Fly   427 ALMVQQQQQQQQQQQLSASLEDNNCASTLIGQ----CLEVLNN-----EAQPI----DEF----N 474
                            :|.|..:..|:...|.    .|:.|..     .|.|:    |.|    :
Human   457 ----------------AAGLAPSGHAAAFGGPPGGLLLDALPGPYAAAAAGPLGAAPDRFPADLD 505

  Fly   475 LENFPVGNLECNVEELLQQEMSYGGLLDINIPLA 508
            |:.|. |:|||:||.::..:......:|.|...|
Human   506 LDMFS-GSLECDVESIILNDFMDSDEMDFNFDSA 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_001262557.1	FH	95..175	CDD:238016	71/79 (90%)
FOXO6	NP_001278210.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..76		18/64 (28%)
		FH	88..168	CDD:238016	71/79 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..235		25/73 (34%)
		FOXO_KIX_bdg	358..>382	CDD:318810	7/50 (14%)
		FOXO-TAD	499..537	CDD:318811	11/38 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4214
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	263	1.000	Inparanoid score	I3087
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1160384at2759
OrthoFinder	1	1.000	-	-		FOG0000837
OrthoInspector	1	1.000	-	-		otm41061
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X489
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	10.070