Protein Alignment foxo and foxo3

DIOPT Version :9

• Sequence 1: NP_001262557.1
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_001096419.1
• Gene: foxo3 / 100125025
• XenbaseID: XB-GENE-945072
• Length: 653
• Species: Xenopus tropicalis
• Alignment Length: 674
• Identity: 218/674 - (32%)
• Similarity: 294/674 - (43%)
• Gaps: 198/674 - (29%)

  Fly    26 GDLPLDVGFEPQTRARSNTWPCPRPE------------------NFVEPTDELDSTKASNQQ--- 69
            ||:.:|..||||:|.||.|||..||:                  :.:.|.:|.|..:.|...
 Frog    12 GDVDIDPDFEPQSRPRSCTWPLQRPDSQGSPGKPNSGAGEAGDASSMIPEEEDDDDEGSGTTATM 76

  Fly    70 ------------LAPGD------------SQQAIQNANAA------------KKNSSRRNAWGNL 98
                        |:.||            :.||......|            :|.|||||||||:
 Frog    77 VGTAGEKGTVVLLSGGDLTVLASPVGGVETLQASLGGGGAGGAQSGATGQQQRKCSSRRNAWGNM 141

  Fly    99 SYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSIRHNLSLHNRFMRVQN 163
            |||||||.||.|:.||||||||||:|||::|||||||||||||||||||||||||||:||:||||
 Frog   142 SYADLITRAIESSQDKRLTLSQIYDWMVRSVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFIRVQN 206

  Fly   164 EGTGKSSWWMLNPE-AKPGKSVRRRAASMETS-RYEKRRGRAKKRVEALRQAGVVGLNDATPSPS 226
            ||:|||||||:||| .|.||:.||||.||:.| :|.|.||||.|:..:|:.:     .|||....
 Frog   207 EGSGKSSWWMINPEGGKGGKAPRRRAVSMDNSNKYTKSRGRAAKKKASLQAS-----TDATDDSP 266

  Fly   227 SSVSEGLDHFPESPL-HSGGGFQLSPDFRQRASSNASS-CGRLSPIRA-------QD-------- 274
            |.:|:    :|.||. .|........|||.|.:||||: .||||||.|       ||
 Frog   267 SQLSK----WPGSPTSRSSDELDAWTDFRSRTNSNASTISGRLSPIPATTELDDVQDDDSPLSPM 327

  Fly   275 -------LEPDWGFPVDYQNTTMT-QAHAQAL-----EELTGTMADELTLCNQQQ---------- 316
                   |.|....|...:...:| .|....|     |.|...:.|:::|.:.||
 Frog   328 LYSSPGSLSPSLSKPCTVEMPRITDMAGTMNLNDGLPENLMDDLLDDISLTSSQQSSPGILMQRS 392

  Fly   317 QGFS-----AASGLPSQ----------PPPPPYQPPQHQQAQQQQQQQSPYALNGPASGYNTLQP 366
            ..|:     :..|.||.          |.....|.|. |..|:.:|           :.::::..
 Frog   393 SSFTYGTKGSGIGSPSNTFNNTSSFNFPLTSLRQSPM-QTIQENKQ-----------ATFSSINH 445

  Fly   367 QSQCLLHRSLNCSCMHNARDGLSPNSVTTTMS-PAYPNSEPSSDSLNTYSNVVL--------DGP 422
            .|...|...||       .|.||.:.|..|.| |....:..:..:.||..|::|        ..|
 Frog   446 YSNQSLQDLLN-------TDTLSHSDVLMTQSDPLMSQASTAVTAQNTRRNIILRNDPMMSFAAP 503

  Fly   423 ADTAALMVQQQQQQQQ---------------------------------QQQLSASLEDNNCAST 454
            ::....:|.|....||                                 |||.|.|......:.|
 Frog   504 SNQGGNLVNQNSLHQQQSLNSFQGGSRALSNNLSNTGLNDSSNLDSTKHQQQSSVSHSMQTISDT 568

  Fly   455 LIGQC------LEVLNNEAQPIDEFNLENFPVGNLECNVEELLQQEMSYGGLLDINIPLATVNTN 513
            |.|..      |..|.:|..|.| .:|:.|. |:|||::|.:::.::.....||.|.      ..
 Frog   569 LSGSLYSSAVNLPTLGHEKFPTD-LDLDIFN-GSLECDMETIIRNDLMDADGLDFNF------DT 625

  Fly   514 LVNSSSGPLSISNISNLSNISSNS 537
            |:::.:..||:.:.:.....||.|
 Frog   626 LISAQNVSLSVGSFTGAKQTSSQS 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foxo	NP_001262557.1	FH	95..175	CDD:238016	68/79 (86%)
foxo3	NP_001096419.1	FH	138..218	CDD:238016	68/79 (86%)
		FOXO_KIX_bdg	420..488	CDD:374715	19/86 (22%)
		FOXO-TAD	587..624	CDD:374716	12/44 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	153	1.000	Domainoid score	I4245
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	230	1.000	Inparanoid score	I3363
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1160384at2759
OrthoFinder	1	1.000	-	-		FOG0000837
OrthoInspector	1	1.000	-	-		otm48265
Panther	1	1.100	-	-	O	PTHR45767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X489
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.070