DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3061 and DNAJB12

DIOPT Version :9

Sequence 1:	NP_650328.1	Gene:	CG3061 / 41707	FlyBaseID:	FBgn0038195	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_001352009.1	Gene:	DNAJB12 / 54788	HGNCID:	14891	Length:	377	Species:	Homo sapiens

Alignment Length:	389	Identity:	168/389 - (43%)
Similarity:	244/389 - (62%)	Gaps:	44/389 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDGNKDEAQRCIDFAVQALAAGKIEKAEKFLLKAERLFPTDNAKKLLAQLKSTPSNESNGKSRTA 65
            |:.|||||:|||..|::|:.:.:.::|.:||.||:||:||...:.|:..|        |.|.:||
Human     1 MESNKDEAERCISIALKAIQSNQPDRALRFLEKAQRLYPTPRVRALIESL--------NQKPQTA 57

  Fly    66 G----ASDEKDSGPRKRVNSDSRS--------SAPDYTKDQLEAVRKVKTCKDYYEVLGVSKTAT 118
            |    .:|...:..||...:|:.|        |...||.:|:.||::||.||||||:||||:.|:
Human    58 GDQPPPTDTTHATHRKAGGTDAPSANGEAGGESTKGYTAEQVAAVKRVKQCKDYYEILGVSRGAS 122

  Fly   119 DSEIKKAYKKLALQLHPDKNKAPGAVEAFKALGNAAGVLTDAEKRKNYDLYGINESHNG-HGNNG 182
            |.::||||::|||:.|||||.||||.|||||:|.|..||::.||||.||.:|.::|... ||
Human   123 DEDLKKAYRRLALKFHPDKNHAPGATEAFKAIGTAYAVLSNPEKRKQYDQFGDDKSQAARHG--- 184

  Fly   183 GGHHGHGQYYNNEYGYSRGFQADISAEELFNMFFNGGFPQQNVH------MRQQRRRQQAREDRE 241
               ||||.::       |||:||||.|:||||||.||||..|||      ||...:::|.|.|.:
Human   185 ---HGHGDFH-------RGFEADISPEDLFNMFFGGGFPSSNVHVYSNGRMRYTYQQRQDRRDNQ 239

  Fly   242 GNNS-SALVNLLPIVLLIGLSMMSSFFISDPMYSLT--PSHKYSVKRETNSLKVPYYVKDNFYSE 303
            |:.. ...|.|:||::||.:|.:|...:|.|.|||:  ||..:..:|.|:.|.|.|||.|.|..|
Human   240 GDGGLGVFVQLMPILILILVSALSQLMVSSPPYSLSPRPSVGHIHRRVTDHLGVVYYVGDTFSEE 304

  Fly   304 YQG-SVARLEESVEEDFVNHLKHSCSRERNYRDSMLAKARTFGDRDLYRKAQNINTPSCENLQK 366
            |.| |:..:|.:||:|::.:|:::|.:|:..::.:|.:||.|||.|:|.:||.:.||||..|.:
Human   305 YTGSSLKTVERNVEDDYIANLRNNCWKEKQQKEGLLYRARYFGDTDMYHRAQKMGTPSCSRLSE 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3061	NP_650328.1	DnaJ	105..>224	CDD:223560	68/119 (57%)
		DnaJ	106..167	CDD:278647	39/60 (65%)
		DUF1977	269..366	CDD:286411	42/99 (42%)
DNAJB12	NP_001352009.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..92		13/54 (24%)
		DnaJ	110..>236	CDD:333066	73/138 (53%)
		DUF1977	268..368	CDD:312722	42/99 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154081
Domainoid	1	1.000	92	1.000	Domainoid score	I7603
eggNOG	1	0.900	-	-		E2759_KOG0714
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9749
Inparanoid	1	1.050	299	1.000	Inparanoid score	I2715
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55696
OrthoDB	1	1.010	-	-		D1173544at2759
OrthoFinder	1	1.000	-	-		FOG0001005
OrthoInspector	1	1.000	-	-		otm41056
orthoMCL	1	0.900	-	-		OOG6_101281
Panther	1	1.100	-	-	LDO	PTHR43908
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2148
SonicParanoid	1	1.000	-	-		X535
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800