DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3061 and dnajb12a

DIOPT Version :9

Sequence 1:	NP_650328.1	Gene:	CG3061 / 41707	FlyBaseID:	FBgn0038195	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_997824.1	Gene:	dnajb12a / 324005	ZFINID:	ZDB-GENE-030131-2725	Length:	371	Species:	Danio rerio

Alignment Length:	385	Identity:	179/385 - (46%)
Similarity:	254/385 - (65%)	Gaps:	45/385 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDGNKDEAQRCIDFAVQALAAGKIEKAEKFLLKAERLFPTDNAKKLLAQL-----KSTPSNESNG 60
            ||.|||||.|||:.|:.||...:.:||.:||.||:||||||.|:.||..:     .|| |.|:||
Zfish     1 MDSNKDEADRCIEIAIAALRDNEQDKARRFLEKAQRLFPTDKARSLLESIIMNGGPST-SEENNG 64

  Fly    61 -----KSRTAGASDEKDSGPRKRVNSDSRSSAPDYTKDQLEAVRKVKTCKDYYEVLGVSKTATDS 120
                 ::|.....|: .||     :|.:.|:.| ||.:||:||:::|.||||||.|||||.|::.
Zfish    65 EPHGLRNRNHKTEDQ-SSG-----HSATESAKP-YTSEQLDAVKRIKRCKDYYETLGVSKEASEE 122

  Fly   121 EIKKAYKKLALQLHPDKNKAPGAVEAFKALGNAAGVLTDAEKRKNYDLYGINESHNGHGNNGGGH 185
            ::||||:||||:.|||||.||||.|||||:|||..||::.|||:.||:||..::|        ..
Zfish   123 DLKKAYRKLALKFHPDKNHAPGATEAFKAIGNAYAVLSNPEKRRQYDVYGEEKAH--------PT 179

  Fly   186 HGHGQYYNNEYGYSRGFQADISAEELFNMFFNGGFPQQNVH------MR--QQRRRQQAREDREG 242
            |.|..|:.|       |:||||.|:||||||.||||..|||      ||  .|:|.::..:.|||
Zfish   180 HRHRTYHRN-------FEADISPEDLFNMFFGGGFPTSNVHVYSNGRMRFGHQQRHERQEQQREG 237

  Fly   243 NNSSALVNLLPIVLLIGLSMMSSFFISDPMYSLT--PSHKYSVKRETNSLKVPYYVKDNFYSEYQ 305
             ..:..|.|:||::||.:|.:|...:|.|.|||:  ||..::.:|:|.:|||||||.|:|..||:
Zfish   238 -GLALFVQLMPILILIIVSALSQMMVSSPPYSLSHRPSLGHTSRRQTATLKVPYYVGDHFSEEYK 301

  Fly   306 G-SVARLEESVEEDFVNHLKHSCSRERNYRDSMLAKARTFGDRDLYRKAQNINTPSCENL 364
            | ::..:|:|||||::::|:::|.:|:..::.:|.:||.|||.|||::||.:.||||..|
Zfish   302 GMNLKNVEQSVEEDYISNLRNNCWKEKQQKEGLLYRARYFGDADLYQRAQKMATPSCSKL 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3061	NP_650328.1	DnaJ	105..>224	CDD:223560	66/118 (56%)
		DnaJ	106..167	CDD:278647	40/60 (67%)
		DUF1977	269..366	CDD:286411	46/99 (46%)
dnajb12a	NP_997824.1	DnaJ	107..>211	CDD:223560	66/118 (56%)
		DnaJ	108..169	CDD:278647	40/60 (67%)
		DUF1977	263..363	CDD:286411	46/99 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589212
Domainoid	1	1.000	97	1.000	Domainoid score	I7174
eggNOG	1	0.900	-	-		E2759_KOG0714
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9749
Inparanoid	1	1.050	321	1.000	Inparanoid score	I2498
OMA	1	1.010	-	-		QHG55696
OrthoDB	1	1.010	-	-		D1173544at2759
OrthoFinder	1	1.000	-	-		FOG0001005
OrthoInspector	1	1.000	-	-		otm25837
orthoMCL	1	0.900	-	-		OOG6_101281
Panther	1	1.100	-	-	LDO	PTHR43908
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2148
SonicParanoid	1	1.000	-	-		X535
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800