DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3061 and DNAJC18

DIOPT Version :9

Sequence 1:	NP_650328.1	Gene:	CG3061 / 41707	FlyBaseID:	FBgn0038195	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_689899.1	Gene:	DNAJC18 / 202052	HGNCID:	28429	Length:	358	Species:	Homo sapiens

Alignment Length:	299	Identity:	114/299 - (38%)
Similarity:	183/299 - (61%)	Gaps:	32/299 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 YTKDQLEAVRKVKTCKDYYEVLGVSKTATDSEIKKAYKKLALQLHPDKNKAPGAVEAFKALGNAA 154
            |:::||..|:::|.|::|||:||||:.|:|.|:||||:||||:.|||||.||||.:||||:|||.
Human    66 YSEEQLLGVQRIKKCRNYYEILGVSRDASDEELKKAYRKLALKFHPDKNCAPGATDAFKAIGNAF 130

  Fly   155 GVLTDAEKRKNYDLYGINESHNGHGNNGGGHHGHGQYYNNEYGYSRGFQADISAEELFNMFFNGG 219
            .||::.:||..||.|| :|.........           ..|.|.|.|:|||:.|||||:||.|.
Human   131 AVLSNPDKRLRYDEYG-DEQVTFTAPRA-----------RPYNYYRDFEADITPEELFNVFFGGH 183

  Fly   220 FPQQNVHM---------------RQQRRRQQAREDREGNNS--SALVNLLPIVLLIGLSMMSSFF 267
            ||..|:||               |.:|.:.|..|:.|...:  ||.:.|||:::::.:|:::...
Human   184 FPTGNIHMFSNVTDDTYYYRRRHRHERTQTQKEEEEEKPQTTYSAFIQLLPVLVIVIISVITQLL 248

  Fly   268 ISDPMYSL--TPSHKYSVKRETNSLKVPYYVKDNFYSEYQG-SVARLEESVEEDFVNHLKHSCSR 329
            .::|.|||  ..:..|::.|||.:|:|||:|..||...|:| |:..||:::|:|::::::.||.:
Human   249 ATNPPYSLFYKSTLGYTISRETQNLQVPYFVDKNFDKAYRGASLHDLEKTIEKDYIDYIQTSCWK 313

  Fly   330 ERNYRDSMLAKARTFGDRDLYRKAQNINTPSCENLQKYL 368
            |:..:..:...|..:.|..|.:||:::...:||.|.|.:
Human   314 EKQQKSELTNLAGLYRDERLKQKAESLKLENCEKLSKLI 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3061	NP_650328.1	DnaJ	105..>224	CDD:223560	60/118 (51%)
		DnaJ	106..167	CDD:278647	38/60 (63%)
		DUF1977	269..366	CDD:286411	33/99 (33%)
DNAJC18	NP_689899.1	DnaJ	82..143	CDD:278647	38/60 (63%)
DNAJC18	NP_689899.1	DUF1977	250..350	CDD:286411	33/99 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	92	1.000	Domainoid score	I7603
eggNOG	1	0.900	-	-		E2759_KOG0714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55696
OrthoDB	1	1.010	-	-		D1173544at2759
OrthoFinder	1	1.000	-	-		FOG0001005
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43908
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2148
SonicParanoid	1	1.000	-	-		X535
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.920