Protein Alignment Cyp6d5 and TBXAS1

DIOPT Version :10

• Sequence 1: NP_650327.1
• Gene: Cyp6d5 / 41706
• FlyBaseID: FBgn0038194
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Alignment Length: 605
• Identity: 142/605 - (23%)
• Similarity: 226/605 - (37%)
• Gaps: 154/605 - (25%)

  Fly     1 MIGIYLLIAAVTLLYVYLKWTFSYWDRKGF----PSTGVSIPF-GALESVTKGKRSFGMAIYDMY 60
            |:.:.|.:|.:.||..|....||..::.|.    ||     || |.|....:|.....|.:..:|
Human    15 MVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPS-----PFIGNLTFFRQGFWESQMELRKLY 74

  Fly    61 KSTKEPVIGLYLTLRPALLVRDAQLAHDVLVKDFASFHDRGVYVDEKNDPMSASLFQMEGASWRA 125
                .|:.|.||..|..:::.:..:...|||::|::|.:|.....|......:.|| :....|..
Human    75 ----GPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLF-LRDKRWEE 134

  Fly   126 LRNKLTPSFTSGKLK----------------------------------------------AMFE 144
            :|..|..:|:..||.                                              .|..
Human   135 VRGALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATLPFCMVP 199

  Fly   145 TSDSVGDKLVDSIRKQLPANGAKELELKKLMATYAIDIIATTIFGLDVDSFADPNNEFQIISKKV 209
            ......|.|:..:::.  |......::::....|..|::|:..||..|||:..|.:.|....|:.
Human   200 LISQACDLLLAHLKRY--AESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRF 262

  Fly   210 ----------------------------NRNNIEDIIRGTSSFLYPGLEKFFVKIGWKQEATERM 246
                                        |:|..|             |..||.|
Human   263 FEFCIPRPILVLLLSFPSIMVPLARILPNKNRDE-------------LNGFFNK----------- 303

  Fly   247 RELSNRTVDLREQNNIV--RKDLLQLLLQLRNQGK-INTDD-----NIWSAESTKNG-------- 295
              |....:.||:|....  |:|.||::|..|:... :...|     :::|:...|..
Human   304 --LIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPS 366

  Fly   296 --VKSMSKDLIAGQLFLFYVAGYETTASTTSFTLYELTQNPEVMEKAKEDVRSAIEKHGGKLTYD 358
              .:.::.|.|.||.|:|.:||||...:|.||..|.|..||:..||...:|....|||.......
Human   367 PMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCS 431

  Fly   359 AISDMKYLEACILETARKYPALPLLNRICTKDYPVPDSKLVIQKGTPIIISLIGMHRDEEYFPDP 423
            ....:.||:..|.||.|.||......|...:|..|...:  |..|..:.:::..:|.|.|::|.|
Human   432 LEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQR--IPAGAVLEMAVGALHHDPEHWPSP 494

  Fly   424 LAYKPERY-LENGKDYTQAAYLPFGEGPRMCIGARMGKVNVKIAIAKVLSNFDLEIRKEKCEIEF 487
            ..:.|||: .|..:.:....|||||.|||.|:|.|:|.:.||:.:..||..|    |.:.|
Human   495 ETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKF----RFQAC---- 551

  Fly   488 GVYGIPLMPKSGVPVRLSLK 507
                    |::.||::|..|
Human   552 --------PETQVPLQLESK 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d5	NP_650327.1	CYP6-like	63..501	CDD:410679	120/530 (23%)
TBXAS1	NP_001159725.2	cytochrome_P450	73..573	CDD:477761	125/542 (23%)