Protein Alignment Cyp6d5 and CYP4F12

DIOPT Version :10

• Sequence 1: NP_650327.1
• Gene: Cyp6d5 / 41706
• FlyBaseID: FBgn0038194
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_076433.3
• Gene: CYP4F12 / 66002
• HGNCID: 18857
• Length: 524
• Species: Homo sapiens
• Alignment Length: 502
• Identity: 120/502 - (23%)
• Similarity: 223/502 - (44%)
• Gaps: 64/502 - (12%)

  Fly     4 IYLLIAAVTLLYVYLKWTFSYWDR----KGFPSTGVSIPF----GALESVTKG-KRSFGM-AIYD 58
            :.||:....||...|.||:::::.    :.||.......|    |.:....:| |.|..| |.|.
Human    21 LLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLGLITPTEEGLKNSTQMSATYS 85

  Fly    59 M-YKSTKEPVIGLYLTLRPALLVRDAQLAHDVLVKDFASFHDRGVYVDEKNDPMSASLFQMEGAS 122
            . :.....|:|...:...|..:......:..:..||       .:::......:...:....|..
Human    86 QGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKD-------NLFIRFLKPWLGEGILLSGGDK 143

  Fly   123 WRALRNKLTPSFTSGKLKAMFETSDSVGDKLVDSIRKQLPANGAKELELKKLMATYAIDIIATTI 187
            |...|..|||:|....||:.....:...:.::|. .:.|.:.|:..|::.:.::...:|.:...|
Human   144 WSRHRRMLTPAFHFNILKSYITIFNKSANIMLDK-WQHLASEGSSRLDMFEHISLMTLDSLQKCI 207

  Fly   188 FGLDVDSFADPNN------EFQIISKKVNRNNIEDIIRGTSSFLY----PGLEKFFVKIGWKQEA 242
            |..|......|:.      |...:.:|.:::.::.:     .|||    .| .:|........:.
Human   208 FSFDSHCQERPSEYIATILELSALVEKRSQHILQHM-----DFLYYLSHDG-RRFHRACRLVHDF 266

  Fly   243 T-----ERMRELSNRTVD--LREQNNIVRKDLLQLLLQLRNQ-GKINTDDNIWSAESTKNGVKSM 299
            |     ||.|.|..:.:|  .:::......|.:.:||..::: ||..:|::|.:...|
Human   267 TDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADT------- 324

  Fly   300 SKDLIAGQLFLFYVAGYETTASTTSFTLYELTQNPEVMEKAKEDVRSAIEKHGGK-LTYDAISDM 363
                     |:|  .|::||||..|:.||.|.::||..|:.:::|:..::....| :.:|.::.:
Human   325 ---------FMF--GGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQL 378

  Fly   364 KYLEACILETARKYPALPLLNRICTKDYPVPDSKLVIQKGTPIIISLIGMHRDEEYFPDPLAYKP 428
            .:|..|:.|:.|.:|..|.::|.||:|..:||.: ||.||...:|.:||:|.:...:|||..|.|
Human   379 PFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGR-VIPKGITCLIDIIGVHHNPTVWPDPEVYDP 442

  Fly   429 ERY-LENGKDYTQAAYLPFGEGPRMCIGARMGKVNVKIAIAKVLSNF 474
            .|: .||.|..:..|::||..|||.|||.......:|:.:|.:|.:|
Human   443 FRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHF 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d5	NP_650327.1	CYP6-like	63..501	CDD:410679	103/432 (24%)
CYP4F12	NP_076433.3	CYP4F	74..515	CDD:410772	108/449 (24%)