Protein Alignment Cyp6d5 and CYP3A43

DIOPT Version :10

• Sequence 1: NP_650327.1
• Gene: Cyp6d5 / 41706
• FlyBaseID: FBgn0038194
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_073731.1
• Gene: CYP3A43 / 64816
• HGNCID: 17450
• Length: 504
• Species: Homo sapiens
• Alignment Length: 521
• Identity: 147/521 - (28%)
• Similarity: 261/521 - (50%)
• Gaps: 56/521 - (10%)

  Fly     6 LLIAAVTLLYVYLKWTFSYWDRKGFPSTGVSIPF-GALESVTKGKRSFGMAIYDMYKSTKEPVIG 69
            |:..::.|||:|...:...:.:.|.|.. ..:|| |.:....:|..:|.....:.|..    :.|
Human    14 LVATSLVLLYIYGTHSHKLFKKLGIPGP-TPLPFLGTILFYLRGLWNFDRECNEKYGE----MWG 73

  Fly    70 LYLTLRPALLVRDAQLAHDVLVKDFASFHDRGVYVDEKN-DPM---SASLFQMEGASWRALRNKL 130
            ||...:|.|::.|..:...||||:..|     |:.::.. .||   .::|...|...|:.:|..|
Human    74 LYEGQQPMLVIMDPDMIKTVLVKECYS-----VFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLL 133

  Fly   131 TPSFTSGKLKAMFETSDSVGDKLVDSIRKQLPANGAKELELKKLMATYAIDIIATTIFGLDVDSF 195
            :|:|||.|.|.|.......||.||.|:|::  |..:|.:.||.....|.:|:|..|:||:::||.
Human   134 SPAFTSVKFKEMVPIISQCGDMLVRSLRQE--AENSKSINLKDFFGAYTMDVITGTLFGVNLDSL 196

  Fly   196 ADPNNEFQIISKKVNRNNIED---IIRGTSSFLYPGLEKFFVKIG--------WKQEATERMREL 249
            .:|.:.|....||:.:.:..|   ::.....||.|..|.  :.||        :.:.:.|||:|
Human   197 NNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEA--LNIGLFPKDVTHFLKNSIERMKE- 258

  Fly   250 SNRTVDLREQNNIVRKDLLQLLLQLRNQGKINTDDNIWSAESTKNGVKSMSKDLIAGQLFLFYVA 314
             :|..|.::.    |.|..|.::..:|            ::.||:.......:|:|..:.:.: |
Human   259 -SRLKDKQKH----RVDFFQQMIDSQN------------SKETKSHKALSDLELVAQSIIIIF-A 305

  Fly   315 GYETTASTTSFTLYELTQNPEVMEKAKEDVRSAIEKHGGKLTYDAISDMKYLEACILETARKYPA 379
            .|:||::|..|.:|||..:|:|.:|.:|:: .|:..:...:||||:..|:||:..:.||.|.:|.
Human   306 AYDTTSTTLPFIMYELATHPDVQQKLQEEI-DAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPV 369

  Fly   380 LPLLNRICTKDYPVPDSKLVIQKGTPIIISLIGMHRDEEYFPDPLAYKPE-RYLENGKDYTQA-A 442
            :..:.|:|.||..:  :.:.|.||..:::.:..:|.|.:|:.:|..:.|| |:.:..||.... .
Human   370 VSRVTRVCKKDIEI--NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYR 432

  Fly   443 YLPFGEGPRMCIGARMGKVNVKIAIAKVLSNFDLEIRKEKCEIEFGVYGIP-LMPKSGVPVRLSL 506
            |:|||.|||.|||.|....|:|:|:.:.|.||..:..|| .:|...:..:| |.|:..:.:::.|
Human   433 YIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKE-TQIPLKLDNLPILQPEKPIVLKVHL 496

  Fly   507 K 507
            :
Human   497 R 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d5	NP_650327.1	CYP6-like	63..501	CDD:410679	133/455 (29%)
CYP3A43	NP_073731.1	cytochrome_P450	67..493	CDD:477761	134/461 (29%)