DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6d5 and Cyp3a57

DIOPT Version :9

Sequence 1:	NP_650327.1	Gene:	Cyp6d5 / 41706	FlyBaseID:	FBgn0038194	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_001093650.1	Gene:	Cyp3a57 / 622127	MGIID:	3646373	Length:	503	Species:	Mus musculus

Alignment Length:	525	Identity:	147/525 - (28%)
Similarity:	250/525 - (47%)	Gaps:	85/525 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLIAAVTLLYVYLKWTFSYWDRKGFPSTGVSIPFGALESVTKGKRSFGMAIYDMYKSTKEPVIGL 70
            ||:.::...|:|..::...:.:.|.|.......||.:.:...|...|....|..|..    :.|.
Mouse    14 LLVTSLVFFYIYGTYSHGLFKKLGIPGPKPLPLFGNIINYLDGMWKFDDDCYKKYGK----IWGF 74

  Fly    71 YLTLRPALLVRDAQLAHDVLVKD-FASFHDRGVYVDEKNDP---MSASLFQMEGASWRALRNKLT 131
            |...:|.|.:.|.::...||||: ::.|.:|..:     .|   :..|:...|...|:.||..|:
Mouse    75 YEGPQPILAIMDPEIIKIVLVKECYSVFTNRRPF-----GPVGFLKKSITISEDEEWKRLRTLLS 134

  Fly   132 PSFTSGKLKAMFETSDSVGDKLVDSIR----KQLPANGAKELELKKLMATYAIDIIATTIFGLDV 192
            |:|||.|||.||......||.||.::|    |:.|.|      :|.:...|::|:|..|..|:::
Mouse   135 PTFTSSKLKEMFPIMRQYGDILVRNLRREEEKEEPIN------MKDIFGAYSMDVITGTSCGVNI 193

  Fly   193 DSFADPNNEFQIISKKVNRNNIEDIIRGTSSFLYPGLE----------------KFFVKIGWKQE 241
            ||..:|.:.|....||:.:....|... .|..|:|.|.                .||.|.
Mouse   194 DSLNNPQDPFVQKIKKILKFKFFDPFL-LSVVLFPFLTPIYEMLNLSIFPRQSMNFFKKF----- 252

  Fly   242 ATERMRELSNRTVDLREQNNIVRKDLLQLLLQLRNQGKINTDDNIWSAESTKNGVKSMSKDLIAG 306
                ::::....:|..::|   |.|.|||::..:|             ...:..:|::|...:|.
Mouse   253 ----VKKMKKDRLDYNQKN---RVDFLQLMMNTQN-------------SKGQESLKALSDLEMAA 297

  Fly   307 QLFLFYVAGYETTASTTSFTLYELTQNPEVMEKAKEDVRSAIEKHGGKLTYDAISDMKYLEACIL 371
            |..:|...||:.|:::.||.:|||..:|:|.:|.::::..|: .:...:||||:.||:||:..:.
Mouse   298 QTLIFIFGGYDGTSTSISFIMYELATHPDVQKKLQDEIDRAL-PNKAPVTYDALMDMEYLDMVVN 361

  Fly   372 ETARKYPALPLLNRICTKDYPVPDSKLVIQKGTPIIISLIGMHRDEEYFPDPLAYKPERY-LENG 435
            |:.|.||.:..::|...||..:  ..:.|.|||.::|.:..:|||.||:|:|..:.|||: .||.
Mouse   362 ESLRLYPVVSRIDRFSKKDVEI--HGVFIPKGTIVMIPIYPLHRDPEYWPEPEDFCPERFSKENK 424

  Fly   436 KDYTQAAYLPFGEGPRMCIGARMGKVNVKIAIAKVLSNFDLEIRKEKCEIEFGVYGIPLMPKSGV 500
            .:.....|:|||.|||.|||.|...::||:|:..||.||.:    :.||            ::.:
Mouse   425 GNIDPYIYMPFGNGPRNCIGMRFALISVKLAVTGVLQNFTV----QPCE------------ETQI 473

  Fly   501 PVRLS 505
            ||::|
Mouse   474 PVKIS 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d5	NP_650327.1	p450	66..478	CDD:278495	130/436 (30%)
Cyp3a57	NP_001093650.1	p450	39..493	CDD:278495	142/500 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820