DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6d5 and Cyp3a25

DIOPT Version :9

Sequence 1:	NP_650327.1	Gene:	Cyp6d5 / 41706	FlyBaseID:	FBgn0038194	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_062766.2	Gene:	Cyp3a25 / 56388	MGIID:	1930638	Length:	503	Species:	Mus musculus

Alignment Length:	518	Identity:	145/518 - (27%)
Similarity:	253/518 - (48%)	Gaps:	71/518 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLIAAVTLLYVYLKWTFSYWDRKGFPSTGVSIPFGALESVTKGKRSFGMAIYDMYKSTKEPVIGL 70
            ||:.::.|.|:|..::...:.:.|.|........|.:.:...|...|....|..|..    :.|.
Mouse    14 LLVTSLVLFYIYGTYSHGLFKKLGIPGPKPLPLLGTIFNYYDGMWKFDEDCYKKYGK----IWGF 74

  Fly    71 YLTLRPALLVRDAQLAHDVLVKD-FASFHDRGVYVDEKNDP---MSASLFQMEGASWRALRNKLT 131
            |...:|.|.:.|.::...||||: ::.|.:|..:     .|   |..::...|...|:.||..|:
Mouse    75 YEGPQPILAIMDPEIIKIVLVKECYSVFTNRRFF-----GPVGFMKKAITISEDEEWKRLRTLLS 134

  Fly   132 PSFTSGKLKAMFETSDSVGDKLVDSIRKQLPANGAKELELKKLMATYAIDIIATTIFGLDVDSFA 196
            |:|||||||.||......||.||.::|::  ....:.:.:|.:...|::|:|..|.||::|||..
Mouse   135 PTFTSGKLKEMFPIMRQYGDILVRNLRRE--EEKGEPISMKDIFGAYSMDVITGTSFGVNVDSLN 197

  Fly   197 DPNNEFQIISKKVNRNNIEDIIRGTSSFLYPGLEKFFVKIGWK----------QEATERMRE--- 248
            :|.:.|...:||:.:..|.|... .|..|:|.|...:..:.:.          ::..:||::
Mouse   198 NPQDPFVQKAKKILKFKIFDPFL-LSIILFPFLTPIYEMLNFSIFPRDSMNFFKKFVKRMKKERL 261

  Fly   249 LSNRTVDLREQNNIVRKDLLQLLLQLRNQGKINTDDNIWSAESTKNGVKSMSKDLIAGQLFLFYV 313
            .||       |.|  |.|.|||::..:|             ...:...|::|...:|.|..:|..
Mouse   262 ASN-------QKN--RVDFLQLMMNTQN-------------SKGQESQKALSDLEMAAQAVIFIF 304

  Fly   314 AGYETTASTTSFTLYELTQNPEVMEKAKEDVRSAIEKHGGKLTYDAISDMKYLEACILETARKYP 378
            .||:.|:::.|..:|||..:|:|.:|.::::...: .:...:||||:.||:||:..:.|:.|.||
Mouse   305 GGYDATSTSISLIMYELATHPDVQKKLQDEIDRTL-PNKAPVTYDALMDMEYLDMVVNESLRLYP 368

  Fly   379 ALPLLNRICTKDYPVPDSKLVIQKGTPIIISLIGMHRDEEYFPDPLAYKPERY-LENGKDYTQAA 442
            ....|.|:..||..:  :.:.|.|||.::|.:..:||:.||:|:|..:.|||: .||..:.....
Mouse   369 IAIRLERVSKKDVEI--NGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPERFSKENKGNIDPYI 431

  Fly   443 YLPFGEGPRMCIGARMGKVNVKIAIAKVLSNFDLEIRKEKCEIEFGVYGIPLMPKSGVPVRLS 505
            |:|||.|||.|||.|...:::|:|:..||.||.:    :.||            ::.:|:::|
Mouse   432 YMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTV----QPCE------------ETQIPLKIS 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d5	NP_650327.1	p450	66..478	CDD:278495	129/429 (30%)
Cyp3a25	NP_062766.2	p450	39..493	CDD:278495	139/493 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820