DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6d5 and Cyp3a73

DIOPT Version :9

Sequence 1:	NP_650327.1	Gene:	Cyp6d5 / 41706	FlyBaseID:	FBgn0038194	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	XP_038945885.1	Gene:	Cyp3a73 / 498198	RGDID:	1595705	Length:	504	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	152/521 - (29%)
Similarity:	256/521 - (49%)	Gaps:	67/521 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YLLIAAV-TLLYVYLKWTFSYWDRKGFPSTGVSIPF-GALESVTKGKRSFGMAIYDMYKSTKEPV 67
            :||:|.: .|.|.:...|...:.::|.|.. ..:|| |.:.:..:|...|.|   :.||...: :
  Rat    12 WLLLAIILVLFYRFGTRTHGIFKKQGIPGP-KPLPFLGTVLNYYRGLWKFDM---ECYKKCGK-I 71

  Fly    68 IGLYLTLRPALLVRDAQLAHDVLVKDFASFHDRGVYVDEKN-DP---MSASLFQMEGASWRALRN 128
            .||:....|...:.|.::...||||:..|     |:.:.:| .|   ||.|:...:...|:..|.
  Rat    72 WGLFDGQTPVFAIMDTEMIKSVLVKECFS-----VFTNRRNIGPVGIMSKSISVAKDEEWKRYRA 131

  Fly   129 KLTPSFTSGKLKAMFETSDSVGDKLVDSIRKQLPANGAKELELKKLMATYAIDIIATTIFGLDVD 193
            .|:|:||||:||.||...:..||.||..:::::  ...|.|.:|::...|::|:|.:|.|.::::
  Rat   132 FLSPTFTSGRLKEMFPIIEHYGDILVKYLKQKV--EKGKPLAMKEVFGAYSMDVITSTSFEVNIN 194

  Fly   194 SFADPNNEFQIISKKVNRNNIEDIIRGTSSFLYPGLEKFFV----------KIGWKQEATERMRE 248
            |..:|.:.|....||..|.:..|.: ..|..|:|.|...:.          .:.:.|:...||::
  Rat   195 SINNPKDPFVEKVKKFQRFDFFDPL-FLSVVLFPFLTPIYEMLNICLFPKDSVAFFQKFVYRMKQ 258

  Fly   249 LSNRTVDLREQNNIVRKDLLQLLLQLRNQGKINTDDNIWSAESTKNGVKSMSKDLIAGQLFLFYV 313
               ..:|.:.::   |.|.|||::...|..|            .|...|::|...|..|..:|..
  Rat   259 ---TRLDSKHKH---RVDFLQLMMNAHNNSK------------DKVSHKALSDIEIVAQAIIFIF 305

  Fly   314 AGYETTASTTSFTLYELTQNPEVMEKAKEDVRSAIEKHGGKLTYDAISDMKYLEACILETARKYP 378
            |.||||:||.||.||.|..:|:..:|.:|::..|:...... |||.:.:|:||:..:.||.|.||
  Rat   306 ASYETTSSTLSFVLYSLATHPDSQKKLQEEIDRALPNKAPP-TYDTVMEMEYLDMVLNETPRLYP 369

  Fly   379 ALPLLNRICTKDYPVPDSKLVIQKGTPIIISLIGMHRDEEYFPDPLAYKPERY-LENGKDYTQAA 442
            ....|.|:|.||..:  ..:.|.||:.::|....:..|.:::|:|..:.|||: .||........
  Rat   370 IGYRLERVCKKDIKL--DGVFIPKGSVVMIPFYTLQHDPQHWPEPEEFLPERFSKENKGSIDPYV 432

  Fly   443 YLPFGEGPRMCIGARMGKVNVKIAIAKVLSNFDLEIRKEKCEIEFGVYGIPLMPKSGVPVRLSLK 507
            |||||.|||.|||.|...:|:|:|:.|||.||..::    ||            ::.:|::||.:
  Rat   433 YLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQL----CE------------ETQIPLKLSRQ 481

  Fly   508 K 508
            :
  Rat   482 R 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d5	NP_650327.1	p450	66..478	CDD:278495	131/426 (31%)
Cyp3a73	XP_038945885.1	CYP3A	67..493	CDD:410743	136/462 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010