DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6d5 and cyp3c3

DIOPT Version :9

Sequence 1:	NP_650327.1	Gene:	Cyp6d5 / 41706	FlyBaseID:	FBgn0038194	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_001007401.2	Gene:	cyp3c3 / 492759	ZFINID:	ZDB-GENE-041114-102	Length:	503	Species:	Danio rerio

Alignment Length:	526	Identity:	155/526 - (29%)
Similarity:	267/526 - (50%)	Gaps:	67/526 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLIAAVTLLYVYLKWTFSYWDRKGFPSTGVSIPFGALESVTKGKRSFGMAIYDMYKSTKEPVIGL 70
            |:...:||||:|..|...::.:.|.|.......||...|.|||..:|.|.....|..    |.|:
Zfish    13 LVFLVITLLYMYGVWPHGFFKKLGIPGPRPWPFFGTFLSYTKGFFNFDMECAKKYGK----VWGI 73

  Fly    71 YLTLRPALLVRDAQLAHDVLVKD-FASFHDRGVYVDEKNDPMSASLFQMEGASWRALRNKLTPSF 134
            |....|.|:|.|.::...::||: :::|.:|.....:...|::..:..::...|:.:|..|:|.|
Zfish    74 YDGRLPILMVTDLEMIKTIMVKECYSTFTNRREVNVDLAGPLADGISAVKDERWKRIRGTLSPYF 138

  Fly   135 TSGKLKAMFETSDSVGDKLVDSIRKQLPANGAKELELKKLMATYAIDIIATTIFGLDVDSFADPN 199
            |||:||.:|..:.:..|:.:.:::|:   :..:.:::|:::|.|::|::.::.|.:|:||..:|:
Zfish   139 TSGRLKEIFPIAMTHADRFIKNMQKR---DHEQPVKIKEVVAPYSLDVVTSSSFSVDIDSINNPD 200

  Fly   200 NEFQIISKKVNRNNIEDIIRGTSSF--------LYPGLEKFFVKIGWKQEATERMRELSN----- 251
            :.|.        .||::.:: .|.|        |:|.:.....|:|    .:...|.:.|
Zfish   201 DPFV--------TNIKNFLK-FSLFSPLILFLTLFPSIANLLGKMG----ISVFSRSIMNFFYTA 252

  Fly   252 -RTVDLREQNNIVRKDLLQLLLQLRNQGKINTDDNIWSAESTKNGVKSMSKDLIAGQLFLFYVAG 315
             |.:....:::..|.|.|:|::|  ||    ..|:.....:::..||.::...|..|.|:|.:.|
Zfish   253 LRKIKDEHKDSNGRVDFLRLMIQ--NQ----IPDDQAKDTTSEQPVKGLTDHEILSQSFIFILGG 311

  Fly   316 YETTASTTSFTLYELTQNPEVMEKAKEDVRSAIEKH---GGKLTYDAISDMKYLEACILETARKY 377
            ||||::|.||.|:.|..||:.:||..|:    |:|:   ...::|||:..|.|||..|.|:.|..
Zfish   312 YETTSTTLSFLLHNLATNPDCLEKLVEE----IDKNFPLDTPISYDALMKMDYLEMSINESMRLL 372

  Fly   378 PALPLLNRICTKDYPVPDSKLVIQKGTPIIISLIGMHRDEEYFPDPLAYKPERYL-ENGKDYTQA 441
            |..|.|.|:|.|  .|..:.:.|.|.|.:.|....::||.:.:..|..::|||:. ||..::.|.
Zfish   373 PTAPRLERVCKK--TVELNGITIPKDTLVAIPTYVLNRDPQLWDSPQEFRPERFSPENKSEFLQY 435

  Fly   442 AYLPFGEGPRMCIGARMGKVNVKIAIAKVLSNFDLEIRKEKCEIEFGVYGIPL------MPKSGV 500
            |::|||.|||.|||.|...:.||:.:.|:|.||.||..||.        .|||      .||  |
Zfish   436 AFMPFGLGPRNCIGMRFALMIVKLLVVKLLQNFSLETCKET--------QIPLELTPVFQPK--V 490

  Fly   501 PVRLSL 506
            |:.|.|
Zfish   491 PITLKL 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d5	NP_650327.1	p450	66..478	CDD:278495	125/430 (29%)
cyp3c3	NP_001007401.2	p450	38..496	CDD:278495	146/499 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.820