DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6d5 and Cyp6a17

DIOPT Version :9

Sequence 1:	NP_650327.1	Gene:	Cyp6d5 / 41706	FlyBaseID:	FBgn0038194	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	174/519 - (33%)
Similarity:	275/519 - (52%)	Gaps:	49/519 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIGIYLLIAAVTLLYVYLKWTFSYWDRKGFPSTGVSIPFGALESVTKGKRSFGMAI---YDMYKS 62
            |:.:.|::..::||....:....||.|:|.|...|...||.::. ...||......   |..||:
  Fly     1 MLLLALIVVILSLLVFAARRRHGYWQRRGIPHDEVHPLFGNIKD-WPNKRHIAEIFRDYYFKYKN 64

  Fly    63 TKEPVIGLYLTLRPALLVRDAQLAHDVLVKDFASFHDRGVYVDEKNDPMSASLFQMEGASWRALR 127
            :..|..|.:.......:|.|.:|...||:|||..|.:|||:.:|.:||:||:||.:||..||.||
  Fly    65 SDYPFAGFFFFFTRTAVVTDMELLKRVLIKDFNHFENRGVFYNEIDDPLSATLFSIEGQKWRHLR 129

  Fly   128 NKLTPSFTSGKLKAMFETSDSVGDKLVDSIRKQLPANGAKELELKKLMATYAIDIIATTIFGLDV 192
            :||||:|||||:|.||.....||:::....|.:..|:..:.||:..|:|.|..|:|....|||:.
  Fly   130 HKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQVLEVVDLVARYTADVIGNCAFGLNC 194

  Fly   193 DSFADPNNEFQIISKKV----NRNNIEDIIRGTSSFLYPGLEKFFVKIGWK---QEATERMRELS 250
            :|..||..||..|.|:.    ...|:.||      ||: |..|...::..|   |||.:...::.
  Fly   195 NSLYDPKAEFVSIGKRAITEHRYGNMLDI------FLF-GFPKLSRRLRLKLNIQEAEDFYTKIV 252

  Fly   251 NRTVDLREQNNIVRKDLLQLLLQL-RNQGKINTDDNIWSAESTKNGVKSMSKDLIAGQLFLFYVA 314
            ..|:|.|.:....|.|.:..|::: :|:...|::|.:     |.|       :|:| |.|:|:||
  Fly   253 RETIDYRLRTKEKRNDFMDSLIEMYKNEQSGNSEDGL-----TFN-------ELLA-QAFIFFVA 304

  Fly   315 GYETTASTTSFTLYELTQNPEVMEKAKEDVRSAIEKHGGKLTYDAISDMKYLEACILETARKYPA 379
            |:||:::|..|.||||.:|.:|.:|.:|::.:...||..:.||:.|.:|||||..::||.||||.
  Fly   305 GFETSSTTMGFALYELARNQDVQDKLREEIGNVFGKHNKEFTYEGIKEMKYLEQVVMETLRKYPV 369

  Fly   380 LPLLNRICTKDYPVPDSKLVIQKGTPIIISLIGMHRDEEYFPDPLAYKPERYL-ENGKDYTQAAY 443
            |..|.|:...|:...|.|..|.|||.::|..:|:|.|.:.:|:|..:||||:. |.........:
  Fly   370 LAHLTRMTDTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEIFKPERFTDEEIAARPSCTW 434

  Fly   444 LPFGEGPRMCIGARMGKVNVKIAIAKVLSNFDLEIRKEKCEIEFGVYGIPLMPKSGVPVRLSLK 507
            ||||||||.|||.|.|.:...:.:|.::..                |...:.|::.:|:::.:|
  Fly   435 LPFGEGPRNCIGLRFGMMQTCVGLAYLIRG----------------YKFSVSPETQIPMKIVVK 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d5	NP_650327.1	p450	66..478	CDD:278495	153/420 (36%)
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	163/478 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461177
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3345
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900