DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6d5 and Cyp6a8

DIOPT Version :9

Sequence 1:	NP_650327.1	Gene:	Cyp6d5 / 41706	FlyBaseID:	FBgn0038194	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	488	Identity:	166/488 - (34%)
Similarity:	279/488 - (57%)	Gaps:	38/488 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YLL----IAAVTLLYVYLKWTFSYWDRKGFPSTGVSIPFGALESV--TKGKRSFGMAIYDMYKST 63
            |:|    :|.:.:|..|:....:|:.|:|.|.....:..|.:|.:  ||.........|:.::.:
  Fly     5 YILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKFRES 69

  Fly    64 KEPVIGLYLTLRPALLVRDAQLAHDVLVKDFASFHDRGVYVDEKNDPMSASLFQMEGASWRALRN 128
            |.|.:|.:....||..|.|.:||..:|:|||::|.::|::.:||:||:||.||.::||.||.|||
  Fly    70 KAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDPISAHLFNLDGAQWRLLRN 134

  Fly   129 KLTPSFTSGKLKAMFETSDSVGDKLVDSIRKQLPANGAKELELKKLMATYAIDIIATTIFGLDVD 193
            ||:.:|||||:|.|:.|..||.::.:..:.:::|.|..  ||::.|:|.:.:|:|.|..||:..:
  Fly   135 KLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSV--LEIRDLVARFTVDVIGTCAFGIQCN 197

  Fly   194 SFADPNNEFQIISKKVNRNNIEDIIRGT--SSFL--YPGLEKFFVKIGWKQEATERMRELSNR-- 252
            |..|...||....|:    ::.|...||  :.|:  ||.|.:   |:|..:.| ..::|..:|
  Fly   198 SLRDEKAEFLYFGKR----SLVDKRHGTLLNGFMRSYPKLAR---KLGMVRTA-PHIQEFYSRIV 254

  Fly   253 --TVDLREQNNIVRKDLLQLLLQLRNQGKINTDDNIWSAESTKNG--VKSMSKDLIAGQLFLFYV 313
              ||.:||:.:|.|.|.:.:|::|:||.::          :.:||  |:.::.:.:..|.|:|::
  Fly   255 TETVAVREKEHIKRNDFMDMLIELKNQKEM----------TLENGDVVRGLTMEEVLAQAFVFFI 309

  Fly   314 AGYETTASTTSFTLYELTQNPEVMEKAKEDVRSAIEKHGGKLTYDAISDMKYLEACILETARKYP 378
            ||:||::||..|.||||.:||::.:|.:.:|...||:|....||:...|:|||...:.||.|.|.
  Fly   310 AGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYT 374

  Fly   379 ALPLLNRICTKDYPVP-DSKLVIQKGTPIIISLIGMHRDEEYFPDPLAYKPERYL-ENGKDYTQA 441
            .:|.|:|:..|.|.|| ....||:.|..:||....:|.|...:|:|..::|||:. |........
  Fly   375 IVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSV 439

  Fly   442 AYLPFGEGPRMCIGARMGKVNVKIAIAKVLSNF 474
            |:||||:|||.|||.|.|::..:|.:|.::.||
  Fly   440 AWLPFGDGPRNCIGLRFGQMQARIGLALLIRNF 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d5	NP_650327.1	p450	66..478	CDD:278495	151/421 (36%)
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	157/454 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461175
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3345
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900