DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6d5 and Cyp6g2

DIOPT Version :9

Sequence 1:	NP_650327.1	Gene:	Cyp6d5 / 41706	FlyBaseID:	FBgn0038194	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_610744.1	Gene:	Cyp6g2 / 36317	FlyBaseID:	FBgn0033696	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	163/525 - (31%)
Similarity:	279/525 - (53%)	Gaps:	36/525 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIGIYLLIAAVTLLYVYLKWTFSYWDRKGF----PSTGVSIPFGALESVTKGKRSFGMAIYDMYK 61
            ::.:.|:.:.:.:.::.|:..:|||.|.|.    |...|....|.| ::......|...:|:...
  Fly     3 LVLLILVASLIGIAFLALQQHYSYWRRMGVREIRPKWIVGNLMGLL-NMRMSPAEFISQLYNHPD 66

  Fly    62 STKEPVIGLYLTLRPALLVRDAQLAHDVLVKDFASFHDRGVYVDEKNDPM-SASLFQMEGASWRA 125
            :..||.:|:::..:||||:||.::..::||||||.|.:|....|.|.||: |.::|.::..:|:.
  Fly    67 AENEPFVGIHVFHKPALLLRDPEMVRNILVKDFAGFSNRYSSSDPKGDPLGSQNIFFLKNPAWKE 131

  Fly   126 LRNKLTPSFTSGKLKAMFETSDSVGDKLVDSIRKQLPANGAK----ELELKKLMATYAIDIIATT 186
            :|.||:|.||..:||.||...:.||..| |:..:|.|.:..:    :||.|:|.|.|..|:|||.
  Fly   132 VRLKLSPFFTGNRLKQMFPLIEEVGASL-DAHLRQQPLHNERMRCFDLEAKELCALYTTDVIATV 195

  Fly   187 IFGLDVDSFADPNNEFQIISKKVNRNNIEDIIRGTSSFLYPGLEKFFVKIGWK---QEATERMRE 248
            .:|:..:||.||..||:...:.|...|:......|..|..|.|..|   :.:|   .|||..:|:
  Fly   196 AYGVSANSFTDPKCEFRRHGRSVFEFNLLRAAEFTLVFFLPHLVPF---VRFKVVPAEATRFLRK 257

  Fly   249 LSNRTVDLREQNNIVRKDLLQLLLQLRNQGKINTDDNIWSAESTKNGVKS---MSKDLIAGQLFL 310
            ..|..:..||::...|.||:.:|::.|...::          :..:|:|.   ...|::..|..|
  Fly   258 TINYVMSEREKSGQKRNDLIDILIEFRRSTQL----------AKASGIKDQFVFEGDILVAQAVL 312

  Fly   311 FYVAGYETTASTTSFTLYELTQNPEVMEKAKEDVRSAIEKHGGKLTYDAISDMKYLEACILETAR 375
            |:.||:|:::||.:|.:|||.::.:|.::.:|:::.|:.:.||::|...|..:::::..:||..|
  Fly   313 FFTAGFESSSSTMAFAMYELAKDTDVQQRLREEIKDALVESGGQVTLKMIESLEFMQMILLEVLR 377

  Fly   376 KYPALPLLNRICT--KDYPVP--DSKLVIQKGTPIIISLIGMHRDEEYFPDPLAYKPERYL-ENG 435
            .||.||.|:|.||  :||.:.  ..|.|:.||.|:.|....:|.|.:|||.|..:.|||:. ||.
  Fly   378 MYPPLPFLDRECTSGRDYSLAPFHKKFVVPKGMPVYIPCYALHMDPQYFPQPRKFLPERFSPENR 442

  Fly   436 KDYTQAAYLPFGEGPRMCIGARMGKVNVKIAIAKVLSNFDLEI-RKEKCEIEFGVYGIPLMPKSG 499
            |.:|...|:|||.||..|||.|.|.:..|:.:..:|.|..:.. .:....::.....|....|.|
  Fly   443 KLHTPYTYMPFGLGPHGCIGERFGYLQAKVGLVNLLRNHMITTSERTPHRMQLDPKAIITQAKGG 507

  Fly   500 VPVRL 504
            :.:||
  Fly   508 IHLRL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d5	NP_650327.1	p450	66..478	CDD:278495	144/427 (34%)
Cyp6g2	NP_610744.1	p450	36..511	CDD:278495	154/489 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461016
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3345
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900