DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6d5 and Cyp6g1

DIOPT Version :9

Sequence 1:	NP_650327.1	Gene:	Cyp6d5 / 41706	FlyBaseID:	FBgn0038194	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_001286335.1	Gene:	Cyp6g1 / 36316	FlyBaseID:	FBgn0025454	Length:	524	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	160/523 - (30%)
Similarity:	276/523 - (52%)	Gaps:	41/523 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IYLLIAAVTLLYVYLKWTFSYWDRKGFPSTGVSIPFGALESVTKGKRSFGMAIYDMYKSTK---E 65
            :::::||:..||.:.:...|||.|||.|....:...|..:.|.|.:.||||.:.::|...:   |
  Fly     7 LFVVVAALVALYTWFQRNHSYWQRKGIPYIPPTPIIGNTKVVFKMENSFGMHLSEIYNDPRLKDE 71

  Fly    66 PVIGLYLTLRPALLVRDAQLAHDVLVKDFASFHDRGVYVDEKNDPMS-ASLFQMEGASWRALRNK 129
            .|:|:|...:|.|::||.:|...:|:|||..||:|....|...||:. .:||.:..|.|:.:|.|
  Fly    72 AVVGIYSMNKPGLIIRDIELIKSILIKDFNRFHNRYARCDPHGDPLGYNNLFFVRDAHWKGIRTK 136

  Fly   130 LTPSFTSGKLKAMFETSDSVGDKLVDSIRKQLPAN-GAKELELKKLMATYAIDIIATTIFGLDVD 193
            |||.|||||:|.|:.....:|..|..:::::...| |:...|:|::.|.::.|.|||..||:..:
  Fly   137 LTPVFTSGKVKQMYTLMQEIGKDLELALQRRGEKNSGSFITEIKEICAQFSTDSIATIAFGIRAN 201

  Fly   194 SFADPNNEFQIISKKVNRNNIEDIIRGTSSFLYPGLE-----KFFVKIGWKQEATERMRELSNRT 253
            |..:||.||:...:|:....:........:|..|.|.     :||.     .:.:..||......
  Fly   202 SLENPNAEFRNYGRKMFTFTVARAKDFFVAFFLPKLVSLMRIQFFT-----ADFSHFMRSTIGHV 261

  Fly   254 VDLREQNNIVRKDLLQLLLQLRNQGKINTDDNIWSAESTKNGVKSMSKDLIAGQLFLFYVAGYET 318
            ::.||::.::|.||:.:|:.||.:.         :||.:|... :.::|.:..|..:|:.||:||
  Fly   262 MEERERSGLLRNDLIDVLVSLRKEA---------AAEPSKPHY-AKNQDFLVAQAGVFFTAGFET 316

  Fly   319 TASTTSFTLYELTQNPEVMEKAKEDVRSAIEKHGGKLTYDAISDMKYLEACILETARKYPALPLL 383
            ::||.||.|||:.::||:.::.::::..|:.:.||.|:|:.|..::||...:.|..|.||.||.|
  Fly   317 SSSTMSFALYEMAKHPEMQKRLRDEINEALVEGGGSLSYEKIQSLEYLAMVVDEVLRMYPVLPFL 381

  Fly   384 NRICTKDYPVPDSKL------VIQKGTPIIISLIGMHRDEEYFPDPLAYKPERYL-ENGKDYTQA 441
            :|........||..|      .::.|||:.|.:..:|.|.:|:.:|..:.|||:. .|.|:....
  Fly   382 DREYESVEGQPDLSLKPFYDYTLENGTPVFIPIYALHHDPKYWTNPSQFDPERFSPANRKNIVAM 446

  Fly   442 AYLPFGEGPRMCIGARMGKVNVKIAIAKVLSNFDLEIRKEKCE-----IEFGVYGIPLMPKSGVP 501
            ||.|||.||..|||:|:|.:..|:.:..:|.|..:    ..||     ::|...|..|....|:.
  Fly   447 AYQPFGSGPHNCIGSRIGLLQSKLGLVSLLKNHSV----RNCEATMKDMKFDPKGFVLQADGGIH 507

  Fly   502 VRL 504
            :.:
  Fly   508 LEI 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d5	NP_650327.1	p450	66..478	CDD:278495	134/425 (32%)
Cyp6g1	NP_001286335.1	p450	56..508	CDD:278495	144/470 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461012
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3345
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900