DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6d5 and Cyp6a13

DIOPT Version :9

Sequence 1:	NP_650327.1	Gene:	Cyp6d5 / 41706	FlyBaseID:	FBgn0038194	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_610390.1	Gene:	Cyp6a13 / 35837	FlyBaseID:	FBgn0033304	Length:	493	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	177/519 - (34%)
Similarity:	287/519 - (55%)	Gaps:	47/519 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIGIYLLIAAV-TLLYVYLKWTFSYWDRKGFPSTGVSIPFGALESVTKGKRS----------FGM 54
            |:.:.:|:..| .||||.|:|.:|||.|:|..        |......:|..|          ..:
  Fly     1 MLTLLVLVFTVGLLLYVKLRWHYSYWSRRGVA--------GERPVYFRGNMSGLGRDLHWTDINL 57

  Fly    55 AIYDMYKSTKEPVIGLYLTLRPALLVRDAQLAHDVLVKDFASFHDRGVYVDEKNDPMSASLFQME 119
            .||..::.. |...|.:..:..:|.:.|.:|..|::::||:||.|||::.:.::||::.:|..::
  Fly    58 RIYRKFRGV-ERYCGYFTFMTKSLFIMDLELIRDIMIRDFSSFADRGLFHNVRDDPLTGNLLFLD 121

  Fly   120 GASWRALRNKLTPSFTSGKLKAMFETSDSVGDKLVDSIRKQLPANGAKELELKKLMATYAIDIIA 184
            |..||.||..||..|||||:|.||.....||:||..:.|.|:     .|:|.|.|.|.:..|:|.
  Fly   122 GPEWRWLRQNLTQVFTSGKMKFMFPNMVEVGEKLTQACRLQV-----GEIEAKDLCARFTTDVIG 181

  Fly   185 TTIFGLDVDSFADPNNEFQIISKKVNRNNIEDIIRGTSSFLYPGLEKFFVKIGWKQEATERMREL 249
            :..|||:.:|..||.::|:.:.:.|.:..:..::.....|..|.|.:......::.|.:|...:.
  Fly   182 SCAFGLECNSLQDPESQFRRMGRSVTQEPLHSVLVQAFMFAQPELARKLRFRLFRPEVSEFFLDT 246

  Fly   250 SNRTVDLREQNNIVRKDLLQLLLQLRNQGKINTDDNIWSAESTKNGVK-SMSKDLIAGQLFLFYV 313
            ..:|:|.|.:.||.|.||:|||::|..:                 ||| ::|.:.||.|..:|::
  Fly   247 VRQTLDYRRRENIHRNDLIQLLMELGEE-----------------GVKDALSFEQIAAQALVFFL 294

  Fly   314 AGYETTASTTSFTLYELTQNPEVMEKAKEDVRSAIEKHGGKLTYDAISDMKYLEACILETARKYP 378
            ||::|:::|.||.||||..||:|.|:.:.:|.:.::::..|||||::.:|.||:..:.||.||||
  Fly   295 AGFDTSSTTMSFCLYELALNPDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYP 359

  Fly   379 ALPLLNRICTKDYPVPDSKLVIQKGTPIIISLIGMHRDEEYFPDPLAYKPERY-LENGKDYTQAA 442
            .||.|.|..||:|.:|:|.|:::.|:.|||.:..:|.|.|.:|||..:.|.|: .|..|.....|
  Fly   360 ILPHLLRRSTKEYQIPNSNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKARHPFA 424

  Fly   443 YLPFGEGPRMCIGARMGKVNVKIAIAKVLSNFDLEIRKEKCEI--EFGVYGIPLMPKSGVPVRL 504
            |||||||||.|||.|.||:.||:.:..:|.:|... |.||.:|  :|......:..:.||.:|:
  Fly   425 YLPFGEGPRNCIGERFGKLQVKVGLVYLLRDFKFS-RSEKTQIPLKFSSRNFLISTQEGVHLRM 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d5	NP_650327.1	p450	66..478	CDD:278495	149/413 (36%)
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	160/466 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461180
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3345
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900