Protein Alignment Cyp6d5 and CYP26C1

DIOPT Version :10

• Sequence 1: NP_650327.1
• Gene: Cyp6d5 / 41706
• FlyBaseID: FBgn0038194
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_899230.2
• Gene: CYP26C1 / 340665
• HGNCID: 20577
• Length: 522
• Species: Homo sapiens
• Alignment Length: 518
• Identity: 99/518 - (19%)
• Similarity: 184/518 - (35%)
• Gaps: 105/518 - (20%)

  Fly     3 GIYLLIAAVTLLYVYLKWTFSYWDRKGFPSTGVSIPFGALESVTKGKRSFGMAIY------DMYK 61
            |..||.|.:.|......||..:...:...|| :.:|.|::     |...||..::      ..:.
Human    16 GTALLCAGLLLSLAQHLWTLRWMLSRDRAST-LPLPKGSM-----GWPFFGETLHWLVQGSRFHS 74

  Fly    62 STKE---PVIGLYLTLRPALLVRDAQLAHDVLVKDFASFHDRGVYVDEKNDPMSA-------SLF 116
            |.:|   .|...:|..||.:.|..|:....:|:.:......:.        |.||       :|.
Human    75 SRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQW--------PQSAHILLGSHTLL 131

  Fly   117 QMEGASWRALRNKLTPSFTSGKLKAMFETSDSVGDKLVDSIRKQLPANGAKELELKKLMATYAID 181
            ...|...|..|..|...|:...|:.........   |...:|....|.|...:.......|:.
Human   132 GAVGEPHRRRRKVLARVFSRAALERYVPRLQGA---LRHEVRSWCAAGGPVSVYDASKALTFR-- 191

  Fly   182 IIATTIFGLDVDSFADPNNEFQIIS-KKVNRNNIEDIIRGTSSFLYPGLEKFFVKIGWKQEATER 245
            :.|..:.||.:|       |.|..: .:.....:|::........:.||.|..           |
Human   192 MAARILLGLRLD-------EAQCATLARTFEQLVENLFSLPLDVPFSGLRKGI-----------R 238

  Fly   246 MRELSNRTVD------LREQNNIVRKDLLQLLLQLRNQGKINTDDNIWSAESTKNGVKSMSKDLI 304
            .|:..:|.::      |.|.......|.|.|::.                .:.:.|.:...::|.
Human   239 ARDQLHRHLEGAISEKLHEDKAAEPGDALDLIIH----------------SARELGHEPSMQELK 287

  Fly   305 AGQLFLFYVAGYETTASTTSFTLYELTQNPEVMEKAKEDVRS---------AIEKHGGK------ 354
            ...:.|.:.|.:.|.:::||..|. |.|:|..:.|.:|::.:         |....||.
Human   288 ESAVELLFAAFFTTASASTSLVLL-LLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEGPPPD 351

  Fly   355 ------LTYDAISDMKYLEACILETARKYPALPLLNRICTKDYPVPDSKLVIQKGTPIIISLIGM 413
                  |:..|:..::|::..:.|..|..|.:....|...:.:.:...:  |.||..::.|:...
Human   352 CGCEPDLSLAALGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQ--IPKGWSVMYSIRDT 414

  Fly   414 HRDEE-YFPDPLAYKPERYLENGKDYTQAA----YLPFGEGPRMCIGARMGKVNVKIAIAKVL 471
            |.... |...|..:.|||:....:|...|:    |:|||.|.|.|:|..:.:..:::...:::
Human   415 HETAAVYRSPPEGFDPERFGAAREDSRGASSRFHYIPFGGGARSCLGQELAQAVLQLLAVELV 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d5	NP_650327.1	CYP6-like	63..501	CDD:410679	84/452 (19%)
CYP26C1	NP_899230.2	CYP26C1	59..508	CDD:410729	87/469 (19%)