DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6d5 and Cyp3a44

DIOPT Version :9

Sequence 1:	NP_650327.1	Gene:	Cyp6d5 / 41706	FlyBaseID:	FBgn0038194	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_796354.1	Gene:	Cyp3a44 / 337924	MGIID:	2449818	Length:	504	Species:	Mus musculus

Alignment Length:	515	Identity:	160/515 - (31%)
Similarity:	257/515 - (49%)	Gaps:	60/515 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IYLLIAAVTLLYVYLKWTFSYWDRKGFPSTGVSIPF-GALESVTKGKRSFGMAIYDMYKSTKEPV 67
            :.||...:.|||.|...|...:.::|.|.. ..:|| |.:.:...|...|.|..|:.|..|
Mouse    12 LVLLAIILVLLYRYGTRTHGLFKKQGIPGP-KPLPFLGTVLNYYTGIWKFDMECYEKYGKT---- 71

  Fly    68 IGLYLTLRPALLVRDAQLAHDVLVKDFAS-FHDR------GVYVDEKNDPMSASLFQMEGASWRA 125
            .||:....|.|::.|.:...:|||||..| |.:|      |:        ||.::...:...|:.
Mouse    72 WGLFDGQTPLLVITDPETIKNVLVKDCLSVFTNRREFGPVGI--------MSKAISISKDEEWKR 128

  Fly   126 LRNKLTPSFTSGKLKAMFETSDSVGDKLVDSIRKQLPANGAKELELKKLMATYAIDIIATTIFGL 190
            .|..|:|:||||:||.||...:..||.||..:|::  |.....:.:|.::..|::|:|.:|.||:
Mouse   129 YRALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQE--AEKGMPVAMKDVLGAYSMDVITSTSFGV 191

  Fly   191 DVDSFADPNNEFQIISKKVNRNNIEDIIRGTSSFLYPGLEKFFVKIG---WKQEATERMRELSNR 252
            :|||..:|.:.|...:||..|.:..|.:. .|..|:|.|...:..:.   :..::.|..::..:|
Mouse   192 NVDSLNNPEDPFVEEAKKFLRVDFFDPLL-FSVVLFPLLTPVYEMLNICMFPNDSIEFFKKFVDR 255

  Fly   253 TVDLR-EQNNIVRKDLLQLLLQLRNQGKINTDDNIWSAESTKNGVKSMSKDLIAGQLFLFYVAGY 316
            ..:.| :.|...|.|.|||::...|..|            .|:..|:.|...|..|..:|..|||
Mouse   256 MQESRLDSNQKHRVDFLQLMMNSHNNSK------------DKDSHKAFSNMEITVQSIIFISAGY 308

  Fly   317 ETTASTTSFTLYELTQNPEVMEKAKEDVRSAIEKHGGKLTYDAISDMKYLEACILETARKYPALP 381
            |||:||.|||||.|..:|::.:|.:.::..|:...... |.|.:.:|:||:..:.||.|.||.:.
Mouse   309 ETTSSTLSFTLYCLATHPDIQKKLQAEIDKALPNKATP-TCDTVMEMEYLDMVLNETLRLYPIVT 372

  Fly   382 LLNRICTKDYPVPDSKLVIQKGTPIIISLIGMHRDEEYFPDPLAYKPERY-LENGKDYTQAAYLP 445
            .|.|:|.||  |..:.:.|.||:.::|....:|.|.:::|||..::|||: .||........|||
Mouse   373 RLERVCKKD--VELNGVYIPKGSMVMIPSYALHHDPQHWPDPEEFQPERFSKENKGSIDPYVYLP 435

  Fly   446 FGEGPRMCIGARMGKVNVKIAIAKVLSNFDLEIRKEKCEIEFGVYGIPLMPKSGVPVRLS 505
            ||.|||.|||.|...:|:|:|:.|||.||..    :.|:            ::.:|::||
Mouse   436 FGIGPRNCIGMRFALMNMKLAVTKVLQNFSF----QPCQ------------ETQIPLKLS 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d5	NP_650327.1	p450	66..478	CDD:278495	138/423 (33%)
Cyp3a44	NP_796354.1	p450	39..494	CDD:278495	152/488 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820