DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6d5 and Cyp6v1

DIOPT Version :9

Sequence 1:	NP_650327.1	Gene:	Cyp6d5 / 41706	FlyBaseID:	FBgn0038194	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_001285499.1	Gene:	Cyp6v1 / 33056	FlyBaseID:	FBgn0031126	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	161/509 - (31%)
Similarity:	263/509 - (51%)	Gaps:	42/509 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLIAAVTLL---YVYLKWTFSYWDRKGFPSTGVSIPFGALESVTKGKRSFGMAIYDMY---KSTK 64
            :|:|.||:|   :::.:.|:.||.|:.......:...|.|..|.:.:.||.:.:...|   :...
  Fly     7 ILLAIVTILTGVFIWSRRTYVYWQRRRVKFVQPTHLLGNLSRVLRLEESFALQLRRFYFDERFRN 71

  Fly    65 EPVIGLYLTLRPALLVRDAQLAHDVLVKDFASFHDRGVYVDEKNDPMSA-SLFQMEGASWRALRN 128
            |||:|:||..:||||:||.||...|||:||.||.:|....|.::|.|.| |||..:...||.:|.
  Fly    72 EPVVGIYLFHQPALLIRDLQLVRTVLVEDFVSFSNRFAKCDGRSDKMGALSLFLAKQPEWREIRT 136

  Fly   129 KLTPSFTSGKLKAMFETSDSVG-------DKLVDSIRKQLPANGAKELELKKLMATYAIDIIATT 186
            :|.|:|...|||.||...:.:|       .:|...:|:.....|| .:.:|.:...|..|:||:.
  Fly   137 RLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGA-IVSIKDVCDLYNTDMIASI 200

  Fly   187 IFGLDVDSFADPNNEFQIISKKVNRNNIEDIIRGTSSFLYPGLEKFFVKIGWKQEATERMRELSN 251
            .|||...|..:..:|.....:.:.|.|:..||.....|..|.|........:.:...|.:|.:..
  Fly   201 AFGLRSYSLRNTQSEIGSHCQDLFRPNVRRIIDLFVIFYLPKLVPLLRPKLFTEPHAEFLRRVIQ 265

  Fly   252 RTVDLREQNNIVRKDLLQLLLQLRNQGKINTDDNIWSAESTKNGVKSMSKDLIAGQLFLFYVAGY 316
            ..::.||:...:|.||:::||.|:.:..:..|.:.::..          :|.:|.|...|.|||.
  Fly   266 LVIEERERGGDLRNDLIEMLLTLKKEADLQQDKSHFTHH----------RDFLAAQAASFEVAGI 320

  Fly   317 ETTASTTSFTLYELTQNPEVMEKAKEDVRSAIEKH-GGKLTYDAISDMKYLEACILETARKYPAL 380
            ||.:::.||.||||.:.|.:..:.:.::|.|...: .|:|||:|::.|::|:..:.||.||||.:
  Fly   321 ETCSASMSFALYELAKQPLMQSRLRREIREAFASNPNGRLTYEAVARMEFLDMVVEETLRKYPIV 385

  Fly   381 PLLNRICTKDYPV---------PDSKLVIQKGTPIIISLIGMHRDEEYFPDPLAYKPERYLENGK 436
            |||.|.||   |:         |.::...::|.|:.||.:.:|.|.:|:|||..:.|||:....|
  Fly   386 PLLERECT---PINKKRFYSLRPHAECYTRRGMPVFISNLAIHHDPKYWPDPDRFDPERFSAANK 447

  Fly   437 DYTQA--AYLPFGEGPRMCIGARMGKVNVKIAIAKVLSNFDLEIRKEKCE-IEF 487
             ..||  :|:|||.|||.|||.::|.:.:|:.:...|....:||.....| |:|
  Fly   448 -ALQAPMSYMPFGAGPRNCIGMQIGLLQIKLGLVYFLHQHRVEICDRTVERIQF 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d5	NP_650327.1	p450	66..478	CDD:278495	140/431 (32%)
Cyp6v1	NP_001285499.1	p450	59..517	CDD:299894	147/457 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461020
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3345
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900