Protein Alignment Cyp6d5 and CYP4X1

DIOPT Version :10

• Sequence 1: NP_650327.1
• Gene: Cyp6d5 / 41706
• FlyBaseID: FBgn0038194
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_828847.1
• Gene: CYP4X1 / 260293
• HGNCID: 20244
• Length: 509
• Species: Homo sapiens
• Alignment Length: 545
• Identity: 127/545 - (23%)
• Similarity: 216/545 - (39%)
• Gaps: 100/545 - (18%)

  Fly    20 WTFSYWDRKGFPSTGVSIPFGALESVTKGKRSFGMAIYDMYKSTKEPVIGLYLTLRPALLVRDAQ 84
            |..:.|.|..:.:....:..|.|:::.                         |.||...|:||.:
Human     5 WLETRWARPFYLAFVFCLALGLLQAIK-------------------------LYLRRQRLLRDLR 44

  Fly    85 ----------LAHDVLVKD--------------------------FASFHD-------------R 100
                      |.|...::|                          |...:|             :
Human    45 PFPAPPTHWFLGHQKFIQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPK 109

  Fly   101 GVYVDEKNDP-MSASLFQMEGASWRALRNKLTPSFTSGKLKAMFETSDSVGDKLVDSIRKQLPAN 164
            ..|:.:.:.| :...|..::|..|...|..|||.|....|||..|........::|...| :.:.
Human   110 SQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEK-ICST 173

  Fly   165 GAKELELKKLMATYAIDIIATTIFGLD----VDSFADPNNEFQIISKKVNRNNIEDIIRGTSSFL 225
            ....:|:.:.:.:.::|||....|..:    .:|..||..:......|:       |.....|.|
Human   174 QDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKI-------IFHRLYSLL 231

  Fly   226 YPGLEKFFVKIGWKQEATERMRELSNRTVDLREQNNIVRKDLLQLLLQLRNQGKINTDDNIWSAE 290
            |.  .....|:..:....:::..:.|:..|...|.   ||..||..::..|..|....|.:....
Human   232 YH--SDIIFKLSPQGYRFQKLSRVLNQYTDTIIQE---RKKSLQAGVKQDNTPKRKYQDFLDIVL 291

  Fly   291 STKNGVKSMSKDL-IAGQLFLFYVAGYETTASTTSFTLYELTQNPEVMEKAKEDVRSAIEKHGGK 354
            |.|:...|...|: :..::..|.:||::|.|::.|:.||.|..|||..|:.:|:|| .|...|..
Human   292 SAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVR-GILGDGSS 355

  Fly   355 LTYDAISDMKYLEACILETARKYPALPLLNRICTKDYPVPDSKLVIQKGTPIIISLIGMHRDEEY 419
            :|:|.:.:|.|...||.||.|..||:|.::|..:|....||. ..:..|..:::|:.|:|.:...
Human   356 ITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDG-CTLPAGITVVLSIWGLHHNPAV 419

  Fly   420 FPDPLAYKPERYLENGKDYTQA-AYLPFGEGPRMCIGARMGKVNVKIAIAKVLSNFDLEIRKEKC 483
            :.:|..:.|.|:.:...|.... |||||..|.|.|||.....:.:|:.||.:|.:|.:.....:
Human   420 WKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTR- 483

  Fly   484 EIEFGVYGIPLMPKSGVPVRLSLKK 508
            .:.|..:.| |.||:|  :.|.|||
Human   484 PLTFPNHFI-LKPKNG--MYLHLKK 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d5	NP_650327.1	CYP6-like	63..501	CDD:410679	118/493 (24%)
CYP4X1	NP_828847.1	CYP4B-like	66..502	CDD:410771	109/454 (24%)
		heme binding region	447..460		6/12 (50%)