DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6d5 and Cyp3a23-3a1

DIOPT Version :9

Sequence 1:	NP_650327.1	Gene:	Cyp6d5 / 41706	FlyBaseID:	FBgn0038194	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_037237.2	Gene:	Cyp3a23-3a1 / 25642	RGDID:	628626	Length:	502	Species:	Rattus norvegicus

Alignment Length:	524	Identity:	150/524 - (28%)
Similarity:	249/524 - (47%)	Gaps:	84/524 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLIAAVTLLYVYLKWTFSYWDRKGFPSTGVSIPFGALESVTKGKRSFGMAIYDMYKSTKEPVIGL 70
            ||...:.|||.:...|...:.::|.|.......||.:.:...|...|.:..:..|..    :.||
  Rat    14 LLAVVLVLLYGFGTRTHGLFKKQGIPGPKPLPFFGTVLNYYMGLWKFDVECHKKYGK----IWGL 74

  Fly    71 YLTLRPALLVRDAQLAHDVLVKD-FASFHDR------GVYVDEKNDPMSASLFQMEGASWRALRN 128
            :....|...:.|.::..:||||: |:.|.:|      |:        |..::...:...|:..|.
  Rat    75 FDGQMPLFAITDTEMIKNVLVKECFSVFTNRRDFGPVGI--------MGKAISVSKDEEWKRYRA 131

  Fly   129 KLTPSFTSGKLKAMFETSDSVGDKLVDSIRKQLPANGAKELELKKLMATYAIDIIATTIFGLDVD 193
            .|:|:||||:||.||...:..||.||..:|::    ..|.:.:|::...|::|:|.:|.||::||
  Rat   132 LLSPTFTSGRLKEMFPVIEQYGDILVKYLRQE----KGKPVPVKEVFGAYSMDVITSTSFGVNVD 192

  Fly   194 SFADPNNEFQIISKKVNRNNIEDIIRGTSSFLYPGLE----------------KFFVKIGWKQEA 242
            |..:|.:.|...:||:.|.:..|.: ..|..|:|.|.                :||.|..::.:.
  Rat   193 SLNNPKDPFVEKAKKLLRIDFFDPL-FLSVVLFPFLTPVYEMLNICMFPKDSIEFFKKFVYRMKE 256

  Fly   243 TERMRELSNRTVDLREQNNIVRKDLLQLLLQLRNQGKINTDDNIWSAESTKNGVKSMSKDLIAGQ 307
            |.         :|..:::   |.|.|||::...|..|            .|....::|...|..|
  Rat   257 TR---------LDSVQKH---RVDFLQLMMNAHNDSK------------DKESHTALSDMEITAQ 297

  Fly   308 LFLFYVAGYETTASTTSFTLYELTQNPEVMEKAKEDVRSAIEKHGGKLTYDAISDMKYLEACILE 372
            ..:|..||||.|:||.||.|:.|..:|:..:|.:|::..|:...... |||.:.:|:||:..:.|
  Rat   298 SIIFIFAGYEPTSSTLSFVLHSLATHPDTQKKLQEEIDRALPNKAPP-TYDTVMEMEYLDMVLNE 361

  Fly   373 TARKYPALPLLNRICTKDYPVPDSKLVIQKGTPIIISLIGMHRDEEYFPDPLAYKPERY-LENGK 436
            |.|.||....|.|:|.||..:  :.:.:.||:.::|....:|||.:::|:|..::|||: .||..
  Rat   362 TLRLYPIGNRLERVCKKDVEI--NGVFMPKGSVVMIPSYALHRDPQHWPEPEEFRPERFSKENKG 424

  Fly   437 DYTQAAYLPFGEGPRMCIGARMGKVNVKIAIAKVLSNFDLEIRKEKCEIEFGVYGIPLMPKSGVP 501
            ......|||||.|||.|||.|...:|:|:|:.|||.||..:..||                :.:|
  Rat   425 SIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKE----------------TQIP 473

  Fly   502 VRLS 505
            ::||
  Rat   474 LKLS 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d5	NP_650327.1	p450	66..478	CDD:278495	132/435 (30%)
Cyp3a23-3a1	NP_037237.2	p450	39..492	CDD:278495	143/499 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920