DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6d5 and cyp-25A4

DIOPT Version :9

Sequence 1:	NP_650327.1	Gene:	Cyp6d5 / 41706	FlyBaseID:	FBgn0038194	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_497779.1	Gene:	cyp-25A4 / 183248	WormBaseID:	WBGene00007967	Length:	501	Species:	Caenorhabditis elegans

Alignment Length:	554	Identity:	136/554 - (24%)
Similarity:	240/554 - (43%)	Gaps:	110/554 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLIAAVTLLYVYLKWTFSYWDRK---------GFPSTGVSIPFGALESVTKGKRSFGMAIYDMYK 61
            :||.:.....:....::|.|.|.         |.|...|...:|.|..:.......|      |.
Worm     3 ILIISTIFFTIITFISYSIWRRHAIFKLRSSIGIPGPPVHWLWGNLNIIKDRVSRLG------YN 61

  Fly    62 STKE----------PVIGLYLTLRPALLVRDAQLAHDVLVKDFASFHDRGVYVDEKNDPMSASLF 116
            .|.:          |:.|||...:..:.|.:.:...::.:::|::|.||          |:..:|
Worm    62 DTTQWHPTLHTKYGPIFGLYCGTQLHITVSEEEDIKEIFIQNFSNFSDR----------MTPDIF 116

  Fly   117 QME-----------GASWRALRNKLTPSFTSGKLKAMFETSDSVGDKLVDSIRKQLPANGAKELE 170
            .|.           ...|:..|:.:.|.|::||:|||.||..|..|..::.::::  ::..::.:
Worm   117 GMNQLNQSLLQNTYATGWKHTRSAIAPIFSTGKMKAMHETLVSKIDIFLEVLKEK--SSSGQKWD 179

  Fly   171 LKKLMATYAIDIIATTIFGLDVDSFADPNNEFQIISKK-VNRNNIEDIIRGTSSFLYPGLEKFFV 234
            :.:...:.::|||....|.:|.:...|..:.|.:.::| |...:::      .|::.| :.....
Worm   180 IFENFQSLSLDIIGKCAFAIDSNCQRDRTDLFYVQARKFVGAVDLK------KSWILP-VSLILP 237

  Fly   235 KIGWKQEATERMRELS-------NRTVDLREQNNIVR-----KDLLQLLLQLRNQGKINTDDNIW 287
            ::.|......:..:||       ...|||.::.....     .|||.||::....||
Worm   238 ELSWLWRFLYKFSDLSAAELPLVKGLVDLYDRRRAGEGGNDSTDLLNLLIRRETIGK-------- 294

  Fly   288 SAESTKNGVKSMSKDLIAGQLFLFYVAGYETTASTTSFTLYELTQNPEVMEKAKEDVRSAIEKHG 352
                       |::..:....|.|.:||||||::...|:.|.|.:.|.|.:|..|:::...|..|
Worm   295 -----------MTQREVIENCFAFLIAGYETTSTAMMFSAYLLAEYPIVQQKLYEEIKKTKENAG 348

  Fly   353 GKLTYDAISDMKYLEACILETARKY-PALPLLNRICTKD-------YPVPDSKLVIQKGTPIIIS 409
              |.||:|.:||||:....|:.|.| |.....||:|..|       || .||.|.:|..|
Worm   349 --LNYDSIHNMKYLDCVYKESLRFYPPTTHFTNRVCLNDMTIRGQIYP-EDSTLKVQPYT----- 405

  Fly   410 LIGMHRDEEYFPDPLAYKPERYLENGKDYTQA-AYLPFGEGPRMCIGARMGKVNVKIAIAKVLSN 473
               :||:...:..|..::|||: ||.::.:.: .::|||.|||.|:|.|..::..|..|||:|..
Worm   406 ---IHRNPANWESPDEFQPERF-ENWEEKSSSLKWIPFGVGPRYCVGMRFAEMEFKTTIAKLLDT 466

  Fly   474 FDLEIRKEKCEIEFGVYGIPLMPKSGVPVRLSLK 507
            |:|.:......:.....|:...|:|  ||||:||
Worm   467 FELSLVPGDPPMIPETNGVIFRPRS--PVRLNLK 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d5	NP_650327.1	p450	66..478	CDD:278495	114/444 (26%)
cyp-25A4	NP_497779.1	p450	37..489	CDD:278495	122/507 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm4722
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.920