DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6d5 and Cyp3a9

DIOPT Version :9

Sequence 1:	NP_650327.1	Gene:	Cyp6d5 / 41706	FlyBaseID:	FBgn0038194	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_671739.2	Gene:	Cyp3a9 / 171352	RGDID:	708392	Length:	503	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	157/521 - (30%)
Similarity:	258/521 - (49%)	Gaps:	77/521 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLIAAVTLLYVYLKWTFSYWDRKGFPSTGVSIPF-GALESVTKGKRSFGMAIYDMYKSTKEPVIG 69
            ||:.::.|||:|...:...:.:.|.|.. ..:|| |.:.:..||...|....:..|..    :.|
  Rat    14 LLVISLVLLYLYGTHSHGIFKKLGIPGP-KPLPFLGTILAYRKGFWEFDKYCHKKYGK----LWG 73

  Fly    70 LYLTLRPALLVRDAQLAHDVLVKD-FASFHDR------GVYVDEKNDPMSASLFQMEGASWRALR 127
            ||...:|.|.:.|..:...||||: :::|.:|      |:        :..::...|...|:.:|
  Rat    74 LYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRNFGPVGI--------LKKAISISEDEEWKRIR 130

  Fly   128 NKLTPSFTSGKLKAMFETSDSVGDKLVDSIRKQLPANGAKELELKKLMATYAIDIIATTIFGLDV 192
            ..|:|:|||||||.||...:...|.||.::|:  .:...|...:|.:...|::|:|..|.||::|
  Rat   131 ALLSPTFTSGKLKEMFPIINQYTDMLVRNMRQ--GSEEGKPTSMKDIFGAYSMDVITATSFGVNV 193

  Fly   193 DSFADPNNEFQIISKKVNRNNIEDIIRGTSSFLYPGLEKFFVK----------IGWKQEATERMR 247
            ||..:|.:.|....||:.:.:|.|.: ..|..|:|.|...|..          |.:.:.:.|||:
  Rat   194 DSLNNPQDPFVEKIKKLLKFDIFDPL-FLSVTLFPFLTPLFEALNVSMFPRDVIDFFKTSVERMK 257

  Fly   248 ELSNRTVDLREQNNIVRKDLLQLLLQLRNQGKINTDDNIWSAESTKNGVKSMSKDLIAGQLFLFY 312
            |  ||..:..:|    |.|.|||::..:|             ...|:..|::|...|..|..:|.
  Rat   258 E--NRMKEKEKQ----RMDFLQLMINSQN-------------SKVKDSHKALSDVEIVAQSVIFI 303

  Fly   313 VAGYETTASTTSFTLYELTQNPEVMEKAKEDVRSAI--EKHGGKLTYDAISDMKYLEACILETAR 375
            .||||||:|..||.||.|..:|::.:|.::::.:|:  :.|.   |||.:..|:||:..:.||.|
  Rat   304 FAGYETTSSALSFVLYLLAIHPDIQKKLQDEIDAALPNKAHA---TYDTLLQMEYLDMVVNETLR 365

  Fly   376 KYPALPLLNRICTKDYPVPDSKLVIQKGTPIIISLIGMHRDEEYFPDPLAYKPERYLENGKD-YT 439
            .||....|.|:|..|..:  :.:.|.|||.::|....:|:|..|:|:|..::|||:.:..:| ..
  Rat   366 LYPIAGRLERVCKTDVEI--NGVFIPKGTVVMIPTFALHKDPHYWPEPEEFRPERFSKKNQDNIN 428

  Fly   440 QAAYLPFGEGPRMCIGARMGKVNVKIAIAKVLSNFDLEIRKEKCEIEFGVYGIPLMPKSGVPVRL 504
            ...|||||.|||.|||.|...:|:|:|:.:||.||..:..||                :.:|::|
  Rat   429 PYMYLPFGNGPRNCIGMRFALMNMKVALVRVLQNFSFQPCKE----------------TQIPLKL 477

  Fly   505 S 505
            |
  Rat   478 S 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d5	NP_650327.1	p450	66..478	CDD:278495	137/431 (32%)
Cyp3a9	NP_671739.2	p450	39..493	CDD:278495	150/496 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820