DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6d5 and Cyp3a62

DIOPT Version :9

Sequence 1:	NP_650327.1	Gene:	Cyp6d5 / 41706	FlyBaseID:	FBgn0038194	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_001019403.1	Gene:	Cyp3a62 / 170509	RGDID:	1595919	Length:	497	Species:	Rattus norvegicus

Alignment Length:	526	Identity:	155/526 - (29%)
Similarity:	252/526 - (47%)	Gaps:	83/526 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLIAAVTLLYVYLKWTFSYWDRKGFPSTGVS----IPF-GALESVTKGKRSFGMAIYDMYKSTKE 65
            ||...:.|||:|...|..     .|...|:|    :|| |.:.:...|...|....:..|..
  Rat    14 LLATILVLLYLYGTSTHG-----NFKKLGISGPKPLPFVGNILAYRHGFWEFDRHCHKKYGD--- 70

  Fly    66 PVIGLYLTLRPALLVRDAQLAHDVLVKD-FASFHDR------GVYVDEKNDPMSASLFQMEGASW 123
             :.|.|...:|.|.:.|..:...||||: :::|.:|      |:        :..::...|...|
  Rat    71 -IWGFYEGRQPILAITDPDIIKTVLVKECYSTFTNRRSFGPAGI--------LKKAITLSEDEEW 126

  Fly   124 RALRNKLTPSFTSGKLKAMFETSDSVGDKLVDSIRKQLPANGAKELELKKLMATYAIDIIATTIF 188
            :.||..|:|:|||||||.||...:...|.||.:::.:  |.....:.:|.:...|::|:|..|.|
  Rat   127 KRLRTLLSPTFTSGKLKEMFPIINQYADLLVKNVKHE--AEKGNPITMKDIFGAYSMDVITGTSF 189

  Fly   189 GLDVDSFADPNNEFQIISKKVNRNNIED-----IIRGTSSFLYPGLEKFFVKIGWK------QEA 242
            |::|||..:|.|.|....||:.:.|..|     :|  ...||.|..|.|.:.:..|      :.:
  Rat   190 GVNVDSLNNPQNPFVQKVKKLLKFNFLDPFFLSVI--LFPFLTPVFEAFDITVFPKDVMKFFRTS 252

  Fly   243 TERMRELSNRTVDLREQNNIVRKDLLQLLLQLRNQGKINTDDNIWSAESTKNGVKSMSKDLIAGQ 307
            .|||:|  ||..:..:|    |.|.|||::..::.|...:...:...|             |..|
  Rat   253 VERMKE--NRMQEKVKQ----RLDFLQLMINSQSSGDKESHQGLTDVE-------------IVAQ 298

  Fly   308 LFLFYVAGYETTASTTSFTLYELTQNPEVMEKAKEDVRSAIEKHGGKLTYDAISDMKYLEACILE 372
            ...|..||||||:|..||.||.|..:|::.:|.::::.:|: .:...:|||.:.:|:||:..:.|
  Rat   299 SIFFIFAGYETTSSALSFALYLLATHPDLQKKLQDEIDAAL-PNKAPVTYDVLVEMEYLDMVLNE 362

  Fly   373 TARKYPALPLLNRICTKDYPVPDSKLVIQKGTPIIISLIGMHRDEEYFPDPLAYKPERYLENGKD 437
            |.|.:|....|.|:|.||..:  :.:.|.|||.:::....:|:|.:.:|:|..:.|||:.:..:|
  Rat   363 TLRLFPVGGRLERVCKKDVEI--NGVFIPKGTVVMVPTFALHKDPKCWPEPEEFCPERFRKKNQD 425

  Fly   438 -YTQAAYLPFGEGPRMCIGARMGKVNVKIAIAKVLSNFDLEIRKEKCEIEFGVYGIPLMPKSGVP 501
             .....|||||.|||.|||.|...:|:|||:.:||.||...:.||                :.:|
  Rat   426 SINPYIYLPFGNGPRNCIGMRFALMNMKIALVRVLQNFSFGLCKE----------------TQIP 474

  Fly   502 VRLSLK 507
            ::|..|
  Rat   475 LKLRKK 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d5	NP_650327.1	p450	66..478	CDD:278495	134/430 (31%)
Cyp3a62	NP_001019403.1	p450	39..491	CDD:278495	146/496 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820