Protein Alignment Cyp6d5 and CYP26A1

DIOPT Version :10

• Sequence 1: NP_650327.1
• Gene: Cyp6d5 / 41706
• FlyBaseID: FBgn0038194
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_000774.2
• Gene: CYP26A1 / 1592
• HGNCID: 2603
• Length: 497
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 126/560 - (22%)
• Similarity: 224/560 - (40%)
• Gaps: 138/560 - (24%)

  Fly     1 MIGIYLLIAAVTLLYVYLKWTFSYWDRK----------GFPSTGVSIPFGALES---VTKGKRSF 52
            ::.:.|.:||:.|..:|   ..|..||.          |||..|.::.. .|:.   :...:|.:
Human    15 VLPLLLFLAAIKLWDLY---CVSGRDRSCALPLPPGTMGFPFFGETLQM-VLQRRKFLQMKRRKY 75

  Fly    53 GMAIYDMYKSTKEPVIGLYLTLRPALLVRDAQLAHDVLVKD--FASFH----DRGVYVDEKNDPM 111
            |.    :||:        :|..||.:.|..|.....:|:.:  ..|.|    .|.:.       .
Human    76 GF----IYKT--------HLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTIL-------G 121

  Fly   112 SASLFQMEGASWRALRNKLTPSFTSGKLKAMFET-SDSVGDKLVDSIRKQLPANGAKEL----EL 171
            |..|..:..:|.:..:..:..:|:...|:..... ::.||..|     :|..:.|.:.|    |:
Human   122 SGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSL-----EQWLSCGERGLLVYPEV 181

  Fly   172 KKLMATYAIDIIATTIFGLDVDSFADPNNEFQIIS--KKVNRNNIEDIIRGTSSFLYPGLEKFFV 234
            |:||...|:.|    :.|.:.....|.::|.|::.  :::.||.....|....|.||.|:
Human   182 KRLMFRIAMRI----LLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGM----- 237

  Fly   235 KIGWKQEATERMRELSNRTVDLREQNNIVR---------------KDLLQLLLQLRNQGKINTDD 284
                      :.|.|.:..:   |||  :|               ||.||||:           :
Human   238 ----------KARNLIHARI---EQN--IRAKICGLRASEAGQGCKDALQLLI-----------E 276

  Fly   285 NIW--SAESTKNGVKSMSKDLIAGQLFLFYVAGYETTASTTSFTLYELTQNPEVMEKAKEDVRS- 346
            :.|  ........:|..|.:|:.|        |:|||||..:..:..|...|.|::|.:|:::|
Human   277 HSWERGERLDMQALKQSSTELLFG--------GHETTASAATSLITYLGLYPHVLQKVREELKSK 333

  Fly   347 ---AIEKHGGKLTYDAISDMKYLEACILETARKYPALPLLNRICTKDYPVPDSKLVIQKGTPIII 408
               .......||..:.:..:||:...|.||.|..|.:|...|:..|.:.:  :...|.||..:|.
Human   334 GLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFEL--NGYQIPKGWNVIY 396

  Fly   409 SLIGMHRDEEYFPDPLAYKPERY-LENGKDYTQAAYLPFGEGPRMCIGARMGKVNVKIAIAKVLS 472
            |:...|...|.|.:...:.|:|: |.:.:|.::.:::|||.|.|.|:|....|:.:||
Human   397 SICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKI------- 454

  Fly   473 NFDLEIRKEKCEIEFGVYGIPLM-------PKSGVPVRLS 505
             |.:|:.:. |:.:. :.|.|.|       |...:|.|.:
Human   455 -FTVELARH-CDWQL-LNGPPTMKTSPTVYPVDNLPARFT 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d5	NP_650327.1	CYP6-like	63..501	CDD:410679	107/479 (22%)
CYP26A1	NP_000774.2	CYP26A1	55..490	CDD:410731	114/514 (22%)