Protein Alignment Cyp6d5 and CYP3A5

DIOPT Version :10

• Sequence 1: NP_650327.1
• Gene: Cyp6d5 / 41706
• FlyBaseID: FBgn0038194
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 156/514 - (30%)
• Similarity: 257/514 - (50%)
• Gaps: 50/514 - (9%)

  Fly     6 LLIAAVTLLYVYLKWTFSYWDRKGFPSTGVSIPFGALESVTKGKRSFGMAIYDMYKSTKEPVIGL 70
            ||..::.|||:|...|...:.|.|.|........|.:.|..:|...|....|..|..    :.|.
Human    14 LLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGK----MWGT 74

  Fly    71 YLTLRPALLVRDAQLAHDVLVKDFASFHDRGVYVDEKN-DP---MSASLFQMEGASWRALRNKLT 131
            |....|.|.:.|..:...||||:..|     |:.:.:: .|   |.:::...|...|:.:|:.|:
Human    75 YEGQLPVLAITDPDVIRTVLVKECYS-----VFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLS 134

  Fly   132 PSFTSGKLKAMFETSDSVGDKLVDSIRKQLPANGAKELELKKLMATYAIDIIATTIFGLDVDSFA 196
            |:|||||||.||......||.||.::|::  |...|.:.||.:...|::|:|..|.||:::||..
Human   135 PTFTSGKLKEMFPIIAQYGDVLVRNLRRE--AEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLN 197

  Fly   197 DPNNEFQIISKKVNRNNIEDIIRGTSSFLYPGLEKFFV----------KIGWKQEATERMRELSN 251
            :|.:.|...:||..:....|.: ..|..|:|.|...|.          .|.:..::..||::  :
Human   198 NPQDPFVESTKKFLKFGFLDPL-FLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKK--S 259

  Fly   252 RTVDLREQNNIVRKDLLQLLLQLRNQGKINTDDNIWSAESTKNGVKSMSKDLIAGQLFLFYVAGY 316
            |..|.::.    |.|.|||::..:|           |.|:..:  |::|...:|.|..:|..|||
Human   260 RLNDKQKH----RLDFLQLMIDSQN-----------SKETESH--KALSDLELAAQSIIFIFAGY 307

  Fly   317 ETTASTTSFTLYELTQNPEVMEKAKEDVRSAIEKHGGKLTYDAISDMKYLEACILETARKYPALP 381
            |||:|..|||||||..:|:|.:|.:::: .|:..:....||||:..|:||:..:.||.|.:|...
Human   308 ETTSSVLSFTLYELATHPDVQQKLQKEI-DAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI 371

  Fly   382 LLNRICTKDYPVPDSKLVIQKGTPIIISLIGMHRDEEYFPDPLAYKPERYLENGKDYTQAAYLPF 446
            .|.|.|.||..:  :.:.|.||:.::|....:|.|.:|:.:|..::|||:.:.........|.||
Human   372 RLERTCKKDVEI--NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPF 434

  Fly   447 GEGPRMCIGARMGKVNVKIAIAKVLSNFDLEIRKE-KCEIEFGVYGIPLMPKSGVPVRL 504
            |.|||.|||.|...:|:|:|:.:||.||..:..|| :..::....|: |.|:..:.:::
Human   435 GTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGL-LQPEKPIVLKV 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d5	NP_650327.1	CYP6-like	63..501	CDD:410679	140/452 (31%)
CYP3A5	NP_000768.1	CYP3A	67..491	CDD:410743	141/458 (31%)