DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6d5 and CYP3A7

DIOPT Version :9

Sequence 1:	NP_650327.1	Gene:	Cyp6d5 / 41706	FlyBaseID:	FBgn0038194	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_000756.3	Gene:	CYP3A7 / 1551	HGNCID:	2640	Length:	503	Species:	Homo sapiens

Alignment Length:	515	Identity:	158/515 - (30%)
Similarity:	249/515 - (48%)	Gaps:	64/515 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLIAAVTLLYVYLKWTFSYWDRKGFPSTGVSIPF-GALESVTKGKRSFGMAIYDMYKSTKEPVIG 69
            ||..::.|||:|...|...:.:.|.|.. ..:|| |...|..||..:|.|..|..|:.    |.|
Human    14 LLAVSLILLYLYGTRTHGLFKKLGIPGP-TPLPFLGNALSFRKGYWTFDMECYKKYRK----VWG 73

  Fly    70 LYLTLRPALLVRDAQLAHDVLVKD-FASFHDRGVYVDEKNDP---MSASLFQMEGASWRALRNKL 130
            :|...:|.|.:.|..:...||||: ::.|.:|..:     .|   |..::...|...|:.:|:.|
Human    74 IYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPF-----GPVGFMKNAISIAEDEEWKRIRSLL 133

  Fly   131 TPSFTSGKLKAMFETSDSVGDKLVDSIRKQLPANGAKELELKKLMATYAIDIIATTIFGLDVDSF 195
            :|:|||||||.|.......||.||.::|::  |...|.:.||.:...|::|:|.:|.||:.:||.
Human   134 SPTFTSGKLKEMVPIIAQYGDVLVRNLRRE--AETGKPVTLKHVFGAYSMDVITSTSFGVSIDSL 196

  Fly   196 ADPNNEFQIISKKVNR-NNIEDIIRGTS--SFLYPGLEKF-----------FVKIGWKQEATERM 246
            .:|.:.|...:||:.| |.::..:....  .||.|.||..           |:....||....|:
Human   197 NNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRL 261

  Fly   247 RELSNRTVDLREQNNIVRKDLLQLLLQLRNQGKINTDDNIWSAESTKNGVKSMSKDLIAGQLFLF 311
            :|....           |.|.|||::..:|.....|.             |::|...:..|..:|
Human   262 KETQKH-----------RVDFLQLMIDSQNSKDSETH-------------KALSDLELMAQSIIF 302

  Fly   312 YVAGYETTASTTSFTLYELTQNPEVMEKAKEDVRSAIEKHGGKLTYDAISDMKYLEACILETARK 376
            ..||||||:|..||.:|||..:|:|.:|.::::.:.:...... |||.:..::||:..:.||.|.
Human   303 IFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPP-TYDTVLQLEYLDMVVNETLRL 366

  Fly   377 YPALPLLNRICTKDYPVPDSKLVIQKGTPIIISLIGMHRDEEYFPDPLAYKPERYLENGKDYTQA 441
            :|....|.|:|.||..:  :.:.|.||..::|....:|.|.:|:.:|..:.|||:.:..||....
Human   367 FPVAMRLERVCKKDVEI--NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDP 429

  Fly   442 -AYLPFGEGPRMCIGARMGKVNVKIAIAKVLSNFDLEIRKE---KCEIEFGVYGIPLMPK 497
             .|.|||.|||.|||.|...||:|:|:.:||.||..:..||   ..::.||  |:.|..|
Human   430 YIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFG--GLLLTEK 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d5	NP_650327.1	p450	66..478	CDD:278495	132/430 (31%)
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	150/490 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920