DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6d5 and Cyp3a11

DIOPT Version :9

Sequence 1:	NP_650327.1	Gene:	Cyp6d5 / 41706	FlyBaseID:	FBgn0038194	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_031844.1	Gene:	Cyp3a11 / 13112	MGIID:	88609	Length:	504	Species:	Mus musculus

Alignment Length:	525	Identity:	161/525 - (30%)
Similarity:	258/525 - (49%)	Gaps:	84/525 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLIAAVTLLYVYLKWTFSYWDRKGFPSTGVSIPF-GALESVTKGKRSFGMAIYDMYKSTKEPVIG 69
            ||..::.|||.|.......:.::|.|.. ..:|| |.:.:..||...|.|..|..|..|    .|
Mouse    14 LLAISLVLLYRYGTRKHELFKKQGIPGP-KPLPFLGTVLNYYKGLWKFDMECYKKYGKT----WG 73

  Fly    70 LYLTLRPALLVRDAQLAHDVLVKD-FASFHDR------GVYVDEKNDPMSASLFQMEGASWRALR 127
            |:....|.|.|.|.:...:||||: |:.|.:|      |:        ||.::...:...|:..|
Mouse    74 LFDGQTPLLAVTDPETIKNVLVKECFSVFTNRRDFGPVGI--------MSKAISISKDDEWKRYR 130

  Fly   128 NKLTPSFTSGKLKAMFETSDSVGDKLVDSIRKQLPANGAKELELKKLMATYAIDIIATTIFGLDV 192
            ..|:|:|||||||.||...:..||.||..:|::  |...|.:.:|.::..|::|:|.:|.||::|
Mouse   131 ALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQK--AKKGKPVTMKDVLGAYSMDVITSTSFGVNV 193

  Fly   193 DSFADPNNEFQIISKKVNRNNIEDIIRGTSSFLYPGLE----------------KFFVKIGWKQE 241
            ||..:|.:.|...:||:.|.:..|.:. .|..|:|.|.                :||.|.
Mouse   194 DSLNNPEDPFVEKAKKLLRFDFFDPLL-FSVVLFPFLTPVYEMLNICMFPKDSIEFFKKF----- 252

  Fly   242 ATERMRELSNRTVDLREQNNIVRKDLLQLLLQLRNQGKINTDDNIWSAESTKNGVKSMSKDLIAG 306
             .:||:|   ..:|.::::   |.|.|||::...|..|            .|...|::|...|..
Mouse   253 -VDRMKE---SRLDSKQKH---RVDFLQLMMNSHNNSK------------DKVSHKALSDMEITA 298

  Fly   307 QLFLFYVAGYETTASTTSFTLYELTQNPEVMEKAKEDVRSAIEKHGGKLTYDAISDMKYLEACIL 371
            |..:|..||||||:||.||||:.|..:|::.:|.::::..|:...... |||.:.:|:||:..:.
Mouse   299 QSIIFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEALPNKAPP-TYDTVMEMEYLDMVLN 362

  Fly   372 ETARKYPALPLLNRICTKDYPVPDSKLVIQKGTPIIISLIGMHRDEEYFPDPLAYKPERY-LENG 435
            ||.|.||....|.|:|.||  |..:.:.|.||:.::|....:|.|.:::.:|..::|||: .||.
Mouse   363 ETLRLYPIANRLERVCKKD--VELNGVYIPKGSTVMIPSYALHHDPQHWSEPEEFQPERFSKENK 425

  Fly   436 KDYTQAAYLPFGEGPRMCIGARMGKVNVKIAIAKVLSNFDLEIRKEKCEIEFGVYGIPLMPKSGV 500
            .......|||||.|||.|:|.|...:|:|:|:.|::.||..:..||                :.:
Mouse   426 GSIDPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKE----------------TQI 474

  Fly   501 PVRLS 505
            |::||
Mouse   475 PLKLS 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d5	NP_650327.1	p450	66..478	CDD:278495	138/435 (32%)
Cyp3a11	NP_031844.1	p450	39..494	CDD:278495	154/500 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820