Protein Alignment Cyp6d5 and CYP4F8

DIOPT Version :10

• Sequence 1: NP_650327.1
• Gene: Cyp6d5 / 41706
• FlyBaseID: FBgn0038194
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_009184.1
• Gene: CYP4F8 / 11283
• HGNCID: 2648
• Length: 520
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 129/501 - (25%)
• Similarity: 222/501 - (44%)
• Gaps: 62/501 - (12%)

  Fly     4 IYLLIAAVTLLYVYLKWTFSYWDR----KGFPSTGVSIPF-GALESVTKGKRSFGMAIYDMYKST 63
            :.|::.|..||...|.||::::..    :.||.......| |.|..||..:.  |:.:.....:|
Human    21 LLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWFLGHLGLVTPTEE--GLRVLTQLVAT 83

  Fly    64 KEPVIGLYLTLRPALLVRDAQLAHDVLVKDFA----SFHDRGVYVDEKNDP-MSASLFQMEGASW 123
            ...  |....|.|...:  ..|.|..:|:...    :..|:.:...:...| :...|....|..|
Human    84 YPQ--GFVRWLGPITPI--INLCHPDIVRSVINTSDAITDKDIVFYKTLKPWLGDGLLLSVGDKW 144

  Fly   124 RALRNKLTPSFTSGKLK---AMFETSDSVGDKLVDSIRKQLPANGAKELELKKLMATYAIDIIAT 185
            |..|..|||:|....||   .:|..|.::    :.:..::|...|:..|::.:.::...:|.:..
Human   145 RHHRRLLTPAFHFNILKPYIKIFSKSANI----MHAKWQRLAMEGSTCLDVFEHISLMTLDSLQK 205

  Fly   186 TIFGLDVDSFADPNNEFQIISK----KVNRNN----IEDIIRGTSSFLYPGLEKFFVKIGWKQEA 242
            .||..|.:....|:.....|.:    .|.|||    .:|.:    .||.|...:|........:.
Human   206 CIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFFRYKDFL----YFLTPCGRRFHRACRLVHDF 266

  Fly   243 T-----ERMRELSNRTVDLREQNNIVRKDLLQLLLQLRNQGKINTDD--NIWSAESTKNGVKSMS 300
            |     ||.|.|:::.||          |.||.      :.|..|.|  ::......||| |.:|
Human   267 TDAVIQERRRTLTSQGVD----------DFLQA------KAKSKTLDFIDVLLLSEDKNG-KELS 314

  Fly   301 KDLIAGQLFLFYVAGYETTASTTSFTLYELTQNPEVMEKAKEDVRSAI-EKHGGKLTYDAISDMK 364
            .:.|..:...|...|::||||..|:.||.|.::||..|:.:::|:..: ::...::.:|.::.:.
Human   315 DEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLP 379

  Fly   365 YLEACILETARKYPALPLLNRICTKDYPVPDSKLVIQKGTPIIISLIGMHRDEEYFPDPLAYKPE 429
            :|..|:.|:.|.:|.:|...|.||:|..:|||: ||.||....|::..:|.:...:|||..|.|.
Human   380 FLTMCLKESLRLHPPIPTFARGCTQDVVLPDSR-VIPKGNVCNINIFAIHHNPSVWPDPEVYDPF 443

  Fly   430 RY-LENGKDYTQAAYLPFGEGPRMCIGARMGKVNVKIAIAKVLSNF 474
            |: .||.:..:..|::||..|||.|||.:.....:|:.:|..|..|
Human   444 RFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRF 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d5	NP_650327.1	CYP6-like	63..501	CDD:410679	114/437 (26%)
CYP4F8	NP_009184.1	CYP4F	74..515	CDD:410772	114/446 (26%)