Protein Alignment Cyp6d5 and cyp3a4

DIOPT Version :10

• Sequence 1: NP_650327.1
• Gene: Cyp6d5 / 41706
• FlyBaseID: FBgn0038194
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: XP_002943949.2
• Gene: cyp3a4 / 100494419
• XenbaseID: XB-GENE-984218
• Length: 504
• Species: Xenopus tropicalis
• Alignment Length: 514
• Identity: 147/514 - (28%)
• Similarity: 255/514 - (49%)
• Gaps: 41/514 - (7%)

  Fly     3 GIYLLIAA-VTLLYVYLKWTFSYWDRKGFPSTGVSIPF-GALESVTKGKRSFGMAIYDMYKSTKE 65
            |.::|:|. :.|:.:|..|.:..:.:.|.|.. ..:|| |......||...|.:..:..|..
 Frog    10 GTWILLAVLLVLILLYGIWPYGLFKKMGIPGP-TPLPFIGTFLEFRKGMIQFDIECFKKYGR--- 70

  Fly    66 PVIGLYLTLRPALLVRDAQLAHDVLVKD-FASFHDR---GVYVDEKNDPMSASLFQMEGASWRAL 126
             :.|:|...:|.|.:.|..:...:|||: :.:|.:|   |:     |.|:.:::...|...|:.:
 Frog    71 -MWGMYDGRQPVLAIMDPAIIKTILVKECYTNFTNRRNFGL-----NGPLESAITVAEDEQWKRI 129

  Fly   127 RNKLTPSFTSGKLKAMFETSDSVGDKLVDSIRKQLPANGAKELELKKLMATYAIDIIATTIFGLD 191
            |:.|:|:|||||||.||:......|.||.::  |:..:..:....|.::..|::|:|.:|.|.::
 Frog   130 RSVLSPTFTSGKLKEMFQIMKDYSDILVKNV--QVSVDKDEPCATKDVIGAYSMDVITSTSFSVN 192

  Fly   192 VDSFADPNNEFQIISKKVNRNN-IEDIIRGTSSFLYPGLEKFFVKIGWKQEATERMRELSNRTVD 255
            :||..:|:|.|.|..|.:.:.. :..:|  ..:.::|.|...|..:.......:..:...|....
 Frog   193 IDSLQNPSNPFVIHIKNLLKTGFLSPVI--IFAVIFPFLRPIFEVLNISFFPKDFTQFFMNAVTS 255

  Fly   256 LREQ----NNIVRKDLLQLLLQLRNQGKINTDDNIWSAESTKNGVKSMSKDLIAGQLFLFYVAGY 316
            .||:    ::..|.|||||::          |........:.|..|:::...|..|..:|..|||
 Frog   256 FREKRKKGDHSGRVDLLQLMV----------DSGTTEGNDSSNQHKALTDAEIMAQSLIFIFAGY 310

  Fly   317 ETTASTTSFTLYELTQNPEVMEKAKEDVRSAIEKHGGKLTYDAISDMKYLEACILETARKYPALP 381
            |||::..|:..|.|..:|:|.:|..|::.|.:...... |||.:..|:||:..|.||.|.:|...
 Frog   311 ETTSTALSYLFYNLATHPDVQQKLHEEIDSFLPDKASP-TYDILMQMEYLDMVIQETLRLFPPAG 374

  Fly   382 LLNRICTKDYPVPDSKLVIQKGTPIIISLIGMHRDEEYFPDPLAYKPERY-LENGKDYTQAAYLP 445
            .|.|:..::..:  :.:.|.|||..:|....:.||.||:|:|..::|||: .||....|...:||
 Frog   375 RLERVSKQNVEI--NGVSIPKGTVAMIPAYVLQRDPEYWPEPEEFRPERFSKENRATQTPFTFLP 437

  Fly   446 FGEGPRMCIGARMGKVNVKIAIAKVLSNFDLEIRKEK-CEIEFGVYGIPLMPKSGVPVR 503
            ||:|||.|||.|...:::|:|||.:|.||.:....|. ..:||...|: |.||..:.::
 Frog   438 FGDGPRNCIGLRFALLSMKVAIATLLQNFSVRPCAETLIPMEFSTIGV-LQPKKPIVLK 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d5	NP_650327.1	CYP6-like	63..501	CDD:410679	132/448 (29%)
cyp3a4	XP_002943949.2	CYP3A	67..495	CDD:410743	133/454 (29%)