DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rdx and KLHL11

DIOPT Version :9

Sequence 1:	NP_650326.3	Gene:	rdx / 41704	FlyBaseID:	FBgn0264493	Length:	829	Species:	Drosophila melanogaster
Sequence 2:	NP_060613.1	Gene:	KLHL11 / 55175	HGNCID:	19008	Length:	708	Species:	Homo sapiens

Alignment Length:	162	Identity:	43/162 - (26%)
Similarity:	76/162 - (46%)	Gaps:	12/162 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   654 FSDVTL---SVGGREFQAHKAILAARSDVFAAMFEHEMEERKLNRVAITDVDHE------VLKEM 709
            |.|:||   ..|||||:||:::|||.::.|..:...:..|.:..||.:.....|      .::.:
Human    93 FCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEPGPEPDTVEAV 157

  Fly   710 LRFIYTGKAPNLEKMADDLLAAADKYALEKLKVMCEEALCVNLSVETAAETLILADLHSADQLKA 774
            :.::|||:.........::|..||::.|.:||..|.|.|...|.:........||.:::..||..
Human   158 IEYMYTGRIRVSTGSVHEVLELADRFLLIRLKEFCGEFLKKKLHLSNCVAIHSLAHMYTLSQLAL 222

  Fly   775 QTIDFINTHATDVMETSGWQNMITTHSHLIAE 806
            :..|.|..:...|::.   :...|...|||.:
Human   223 KAADMIRRNFHKVIQD---EEFYTLPFHLIRD 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdx	NP_650326.3	MATH_SPOP	483..621	CDD:239743
		BTB	645..749	CDD:279045	30/103 (29%)
		BTB	656..752	CDD:197585	30/104 (29%)
		SPOP_C	752..814	CDD:269807	12/55 (22%)
KLHL11	NP_060613.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..70
		BTB_POZ_KLHL11	71..205	CDD:349550	32/111 (29%)
		PHA03098	90..553	CDD:222983	43/162 (27%)
		BACK_KLHL11	200..287	CDD:350526	12/55 (22%)
		Kelch 1	360..407
		KELCH repeat	399..439	CDD:276965
		Kelch 2	408..453
		KELCH repeat	443..488	CDD:276965
		Kelch 3	455..501
		KELCH repeat	491..541	CDD:276965
		Kelch 4	503..556
		KELCH repeat	567..649	CDD:276965
		Kelch 5	610..661
		Kelch	611..657	CDD:128874
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910